2型糖尿病患者血清CA199的变化特点及影响因素的分析  

Serum CA199 variance and its related factors in type 2 diabetic patients

作　　者：征海华 戚蓓蓓[2] 宋文春[2] 程雪[2] 雷涛[3] 

机构地区：[1]南京市红十字医院内分泌科 [2]东南大学附属盐城医院内分泌科 [3]同济大学附属同济医院内分泌科

出　　处：《同济大学学报（医学版）》2014年第5期69-74,共6页Journal of Tongji University(Medical Science)

摘　　要：目的探讨2型糖尿病患者CA199的变化特点及相关影响因素。方法收集180例住院2型糖尿病患者,并按Hb AlC水平分为血糖控制差组（A组,56例,Hb A1C〉7.5%）、控制尚可组（B组,59例,Hb A1C 6.5%~7.5%）、控制良好组（C组,65例,Hb A1C〈6.5%）,选取同期60例健康人群作为正常对照组（D组）。检测各组血清CA199、空腹血糖（FBG）、糖化血红蛋白（Hb A1C）、空腹胰岛素（FINS）、空腹C肽（FCP）年龄、性别、体质量指数（BMI）、腰围、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等指标。比较各组CA199的水平,并分析与上述各变量间的相关性。以ln CA199为因变量,其余指标为自变量,进行多元线性回归分析,比较各变量对其影响程度。结果方差分析显示A、B组CA199显著高于C、D组,且A组更高于B组;Spearman相关分析显示CA199水平与FBG（r=0.179,P=0.016）、Hb A1C（r=0.424,P〈0.001）呈正相关;多元线性回归分析显示：Hb A1C是影响ln CA199的独立危险因素（β=0.388,P〈0.001）。结论血清CA199在2型糖尿病患者中有低水平升高,考虑可能与血糖长期控制不佳密切相关。Objective To investigate the variance of serum CA199 levels and its related factors in type 2 diabetic patients. Methods One hundred and eighty hospitalized type 2 diabetic patients were enrolled in the study and were divided into3 groups accordingtoHb A1 c levels： group A（ Hb A1 C 7. 5%,n = 56）,group B（ Hb A1 C 6. 5%-7. 5%,n = 59） and group C（ Hb A1 C 6. 5%,n = 65）;and 60 healthy subjects were alsoenrolled as normal controls（ group D）. The levels of serum CA199,fastingblood glucose,glycosylated hemoglobin,fastinginsulin,fastingC-peptide,age,sex,body mass index,waist circumference,total cholesterol,triglyceride,high density lipoprotein cholesterol,lowdensity lipoprotein cholesterol and other variables were used for analysis. The levels of serum CAl99 were compared amongthe 4 groups,and the correlation of CA199 with other variables was analyzed with multiple linear regression. Results CA199 levels in groups A and B were significantly higher than groups C and D,and that of group A was the highest. Spearman relation analysis showed that the CAl99 level was positively correlated with FBG（ r = 0. 179,P = 0. 016）,Hb A1C（ r = 0. 424,P〈0. 001）. M ultiple linear regression analysis showed that Hb AlC was the independent risk factor for increased CAl9（ β = 0. 388,P〈0. 001）. Conclusion The low-level elevation of serum CA199 in type2 diabetic patients may be closely related tolong-term poor glucose control.

关 键 词：2型糖尿病 糖化血红蛋白 肿瘤标志物 CA199 影响因素 

分 类 号：R587.1[医药卫生—内分泌]