PD-1/PD-L与脓毒症诱导的急性肺损伤关系的研究进展  

PD-1 / PD-L and sepsis-induced acute lung injury

作　　者：程婷婷[1] 李红强[1] 白建文[1] 

机构地区：[1]同济大学附属东方医院急诊内科,上海200120

出　　处：《同济大学学报（医学版）》2014年第5期128-132,共5页Journal of Tongji University(Medical Science)

基　　金：上海市浦东新区科技发展基金创新资金(PKJ2010-Y20)

摘　　要：脓毒症诱导的急性肺损伤发病率高、病死率高,目前可应用的治疗方法有限,且效果欠佳。程序性细胞死亡受体-1(Programmed Cell Death-1,PD-1)及其配体PD-L在脓毒症诱导的急性肺损伤中具有重要作用,可以改变免疫细胞及细胞因子的数量和功能,并影响疾病预后。本文就PD-1/PD-L与脓毒症诱导的急性肺损伤的研究进行综述。Sepsis-induced acute lunginjury is associated with high morbidity and mortality,however,the therapy for this disease is limited and less effective. Programmed cell death-1（ PD-1） and its ligand PD-L has been identified toaffect the cellular and cytokine profiles and modify the disease prognosis,it would be a potential therapeutic modality for sepsis-induced acute lunginjury. The relationship between PD-1 / PD-L and sepsis-induced acute lunginjury is discussed in this review.

关 键 词：共抑制受体 急性呼吸窘迫综合征 固有免疫 巨噬细胞 细胞因子 凋亡 

分 类 号：R631[医药卫生—外科学]