右美托咪定复合雷米芬太尼在中期妊娠引产镇痛的应用  

Application of dexmedetomidine combined with remifentanil for analgesia in puerperants in midpregnancy undergoing induction of labor

作　　者：王伟[1] 沈洁[1] 谢如峰[1] 刘昱升[1] 瞿健[1] 沈晓凤[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院麻醉科,江苏省210004

出　　处：《江苏医药》2014年第24期3002-3004,共3页Jiangsu Medical Journal

摘　　要：目的探讨右美托咪定复合雷米芬太尼在中期妊娠引产镇痛中的应用效果。方法静脉镇痛中期妊娠引产产妇60例随机均分为两组:D1组采用右美托咪定0.1μg·kg-1·h-1和雷米芬太尼0.05μg·kg-1·min-1;D2组右美托咪定改用0.2μg·kg-1·h-1。记录镇痛前、镇痛10、60min和宫口开全时的VAS疼痛评分、Ramsay评分、BP、HR和不良反应。结果两组各时点VAS评分均无统计学差异(P>0.05);镇痛10、60min和宫口开全时,D2组Ramsay评分高于D1组(P<0.05),BP、HR低于D1组(P<0.05)。D2组心动过缓的发生率高于D1组(P<0.05)。结论右美托咪定0.1μg·kg-1·h-1复合雷米芬太尼提供良好镇痛镇静效果,心动过缓发生率低。Objective To investigate the outcomes of different doses of dexmedetomidine combined with remifentanil for analgesia in the puerperants in midpregnancy undergoing induction of labor.Methods Sixty puerperants in midpregnancy undergoing induction of labor were equally and randomly divided into two groups.The patients in group D1 were applied intravenous analgesia with dexmedetomidine 0.1μg·kg-1·h-1 combined with remifentanil 0.05μg·kg-1·min-1,and those in group D2 were given dexmedetomidine 0.2μg·kg-1·h-1 instead of 0.1μg·kg-1·h-1.VAS pain scores and Ramsay scores were recorded before and at 10 and 60 minutes during analgesia,and at the time of full dilatation.The BP,HR and side effects were observed as well.Results There were no significant differences in VAS score at all time points between two groups（P〉0.05）.The Ramsay score was significantly higher,while BP and HR were significantly lower in group D2 than those in group D1 during analgesia（P〈0.05）.The incidence of bradycardia in group D2 was higher than that in group D1（P〈0.05）.Conclusion Dexmedetomidine 0.1μg·kg-1·h-1 combined with remifentanil 0.05μg·kg-1·min-1 provides a satisfactory analgesia and sedative with lower incidence of bradycardia.

关 键 词：右美托咪定 雷米芬太尼 产妇 镇痛 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]