干细胞移植改善骨量:研究进展与应用前景  

Stem cell transplantation improves bone mass: research progress and application prospects

作　　者：曹德宇 李锋[1] 齐宝昶[1] 顾群[1] 王春利[1] 陶树清[1] 

机构地区：[1]哈尔滨医科大学附属第二医院骨二科,黑龙江省哈尔滨市150001

出　　处：《中国组织工程研究》2014年第45期7348-7352,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:研究表明骨量丢失会引发诸如骨质疏松性骨折等一系列疾病,因此寻求增加骨量治疗方法成为广大研究者的目标。目的:对目前干细胞移植用于提高骨量的研究进行总结综述,以期尽早广泛应用于骨质疏松症的临床治疗。方法:由第一作者应用计算机检索Pub Med、中国期刊全文数据库(CNKI)1997年1月至2014年10月相关文献。在标题、摘要、关键词中以"to improve bone mass,regenerative medicine,bone marrow mesenchymal stem cell transplantation,stem cell therapy或"改善骨量,再生医学,干细胞移植,干细胞治疗"为检索词进行检索。选择文章内容与干细胞治疗骨质疏松有关者,同一领域文献则选择近期发表在权威杂志文章,最终选择28篇文献进行综述。结果与结论:骨髓间充质干细胞易于获取和分离培养,可快速增殖,具有多向分化潜能。研究表明骨髓间充质干细胞向成骨细胞分化可以明确提高骨量,在治疗骨科疾病方面取得较多成果。这种新的细胞治疗方法将有助于增加骨愈合的速度,减少治疗时间,为骨外科、整形外科、口腔颌面外科提供一个新的治疗选择,具有广阔的应用前景。BACKGROUND：Studies have shown that bone loss can lead to a series of diseases, such as osteoporotic fractures, thus seeking to increase bone mass has become a goal of the majority of researchers. OBJECTIVE：To summarize the current studies of improving bone mass by using stem cel transplantation, hoping to the extensive application of stem cel transplantation in the clinical treatment of osteoporosis as early as possible. METHODS：A computer-based search of PubMed and CNKI was performed by the first author to retrieve articles relevant to stem cel therapy for osteoporosis published from January 1997 to October 2014. The keywords were“to improve bone mass, regenerative medicine, bone marrow mesenchymal stem cel transplantation, stem cel therapy”in Chinese and English, respectively, which appeared in the title, abstract or keywords. Articles published recently or in authoritative journals were preferred, and final y 28 articles were included in result analysis. RESULTS AND CONCLUSION：Bone marrow mesenchymal stem cel s which are isolated and cultured easily can proliferate rapidly and have multi-lineage differentiation potential. Studies have shown that the osteogenic differentiation of bone marrow mesenchymal stem cel s can real y improve bone mass, and obtain more achievements in the treatment of orthopedic disorders. This new cel therapy can help to accelerate bone healing and reduce treatment time, offering a new therapeutic choice for orthopedic surgery, plastic surgery, oral and maxil ofacial surgery, and therefore, it has broad application prospects.

关 键 词：干细胞 移植 骨髓间充质干细胞 改善骨量 再生医学 干细胞移植 干细胞治疗 

分 类 号：R318[医药卫生—生物医学工程]