三脑室底型颅咽管瘤骨膜蛋白表达及其与下丘脑功能的关系  

Expression of Periostin in Craniopharyngioma Involving Third Ventricular Floor and its Relationship to Hypothalamus Functions

作　　者：陈铭[1] 刘忆[1] 曹永福[1] 潘军[1] 石瑾[1] 汪潮湖[1] 万仁宽 冯展鹏 殷春梅[1] 漆松涛[1] 

机构地区：[1]南方医科大学南方医院神经外科,广州510515

出　　处：《中国神经精神疾病杂志》2014年第11期677-681,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省自然科学基金重点项目(编号:S2011010003063);广东省自然科学基金自由申请项目(编号:S2011020005179);国家临床重点专科建设项目经费资助

摘　　要：目的探讨骨膜蛋白(Periostin,POSTN)在三脑室底内型颅咽管瘤中表达及意义。方法回顾性分析42例手术病理证实的成釉细胞型且外科分型为三脑室底内型的颅咽管瘤患者资料,对其病理切片进行POSTN免疫组化染色,分析染色程度和肿瘤与三脑室底粘连程度、术后下丘脑功能和复发情况的关系。结果POSTN表达于颅咽管瘤间质成分,表达程度和术后复发率无统计学意义(Z=-0.236,P=0.813),但和肿瘤与三脑室底粘连程度(r=0.685,P<0.001)、术后下丘脑评分(r=0.569,P<0.001)及术后随访期BMI(r=0.594,P<0.001)有相关性。结论 POSTN反映三脑室底内型颅咽管瘤和下丘脑粘连程度,其高表达预测着更差的下丘脑功能状态。Objective To evaluate the expression and clinical significance of Periostin （POSTN） in craniopharyngi？oma. Methods Forty-two patients with pathologically diagnosed adamantinomatous craniopharyngioma involving the floor of 3rd ventricle were retrospectively analyzed. The correlation between expression of POSTN and outcome was studied. Results POSTN was expressed in stroma of craniopharyngioma tissues. The expression of POSTN was not associated with the postoperative recurrence （Z=-0.236,P=0.813） while was associated with the degree of the adhesion between tumor and floor of 3rd ventricle （r=0.685, P〈0.001）, postoperative Hypothalamic Status Scale （r=0.569, P〈0.001） and Body Mass Index （r=0.594, P〈0.001）. Conclusions POSTN may predict the degree of the adhesion between craniopharyngioma and 3rd ventricle floor. The high expression of POSTN may indicate the worse hypothalamus function.

关 键 词：颅咽管瘤 骨膜蛋白 下丘脑 预后 

分 类 号：R739.41[医药卫生—肿瘤]