人参茎叶中1个新三萜类天然产物  

A new triterpene natural product from stems and leaves of Panax ginseng

作　　者：李珂珂[1,2] 杨秀伟[1] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,药学院天然药物学系,北京100191 [2]大连大学医学院,辽宁大连116622

出　　处：《中草药》2015年第2期169-173,共5页Chinese Traditional and Herbal Drugs

基　　金："十二五"国家科技支撑计划项目(2011BAI07B08);辽宁省教育厅科学技术研究一般项目(L2012439)

摘　　要：目的研究人参Panax ginseng茎叶总皂苷中的化学成分。方法采用硅胶柱色谱及半制备高效液相色谱等方法进行分离、纯化,通过NMR、MS等谱学方法进行结构鉴定。结果从人参茎叶的总皂苷提取物中分离鉴定了9个化合物,分别为3β,6α,12β,25-四羟基-达玛-E-20(22)-烯-6-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷(1)、三七皂苷B1(2)、3β,6α,12β-达玛-E-20(22)-烯-3,6,12,25-四醇(3)、人参皂苷Rk3(4)、人参皂苷Rh4(5)、三七皂苷T2(6)、3β,6α,12β-达玛-20(21),24-二烯-3,6,12-三醇(7)、人参皂苷Rk1(8)和人参皂苷Rg5(9)。结论化合物1为1个新的天然产物,并首次全面报道了其1H-NMR谱数据;其余化合物均为从人参茎叶中首次分离得到。Objective To study the chemical constituents of saponins in the stems and leaves of Panax ginseng.Methods The chemical constituents were isolated and purified by various chromatographic methods,and their structures were identified by NMR and MS data analysis.Results Nine compounds were isolated and identified as 3β,6α,12β,25-tetrahydroxy-dammar-E-20（22）-ene-6-O-α-L-rhamnopyranosyl-（1→2）-β-D-glucopyranoside（1）,sanchinoside B1（2）,3β,6α,12β-dammar-E-20（22）-ene-3,6,12,25-tetraol（3）,ginsenoside Rk3（4）,ginsenoside Rh4（5）,notoginsenoside T2（6）,3β,6α,12β-dammar-20（21）,24-diene-3,6,12-triol（7）,ginsenoside Rk1（8）,and ginsenoside Rg5（9）.Conclusion Compound 1 is a new natural product and the other eight compounds are all isolated from the stems and leaves of P.ginseng for the first time.

关 键 词：人参茎叶 人参皂苷 3β 6α 12β 25-四羟基-达玛-E-20(22)-烯-6-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷 人参皂苷Rk1 人参皂苷Rg5 

分 类 号：R284.1[医药卫生—中药学]