甲基睾丸素联合米非司酮治疗围绝经期功能性子宫出血的疗效评价  

Methyl testosterone combined with mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding

作　　者：李建华[1] 胡继芬[1] 

机构地区：[1]福建医科大学附属第一医院妇产科,福州350004

出　　处：《中国临床药理学杂志》2015年第2期132-134,共3页The Chinese Journal of Clinical Pharmacology

基　　金：福建省高校教师基金资助项目(JS08012)

摘　　要：目的评价小剂量甲基睾丸素联合米非司酮治疗围绝经期功能性子宫出血(FUB)的疗效及对激素水平的影响。方法 56例FUB患者刮宫后第1天开始服用米非司酮25 mg,甲基睾丸素5 mg,每天1次,共服用90 d,停用米非司酮后继续服用甲基睾丸素15 d后停药。测量治疗前后患者子宫内膜厚度和女性激素变化情况,随访记录2年月经情况。结果治疗后患者子宫内膜厚度显著降低(P<0.05);治疗后雌激素(E)和孕激素(P)水平明显下降(P<0.05);56例患者均已闭经,治疗后9例月经正常,14例月经稀少,33例绝经。随访2年,8例患者再次出现腹痛、阴道不规则流血等症状,复发率为14.3%。结论小剂量甲基睾丸素联合米非司酮治疗围绝经期FUB,可显著降低子宫内膜厚度,临床疗效满意,药物不良反应轻微。Objective To evaluate the clinical efficacy of methyl testos-terone combined with mifepristone on hormone and perimenopausal func-tional uterine bleeding （ FUB）.Methods Fifty-six patients with FUB received methyl testosterone 5 mg qd for 90 days and mifepristone 25 mg qd for 105 days.The endometrial thickness and hormonal were measured before and after the treatment.The data of menstruation were recorded in two-year follow -up.Results The endometrial thickness was signifi-cantly decreased after the treatment （ P 〈0.05 ） and the serum estrogen and progesterone were much lower after treatment than that of before treatment（P〈0.05）.During the period of treatment , all of the fifty -six patients occurred amenorrhea , 9 case with normal menstruation , 14 cases of menstrual scarce and 33 cases of menopause after treatment.With 2 -year follow -up, eight patients had abdominal pain again , irregular vaginal bleeding and other symptoms , and the recurrence rate was 14.3%.Conclusion Methyl testosterone combined with mifepris-tone in the treatment of FUB can significantly reduce the thickness of the endometrium with satisfactory clinical efficacy and mild adverse reactions .

关 键 词：甲基睾丸素 米非司酮 功能性子宫出血 复发 

分 类 号：R711.52[医药卫生—妇产科学] R977.12[医药卫生—临床医学]