带有功能基团纳米纤维支架的制备  

The fabrication of nanofibrous scaffolds with functional group

作　　者：强娜[1] 马毅红[1] 朱庆英[1] 陶海霞[1] 廖芳丽[1] 

机构地区：[1]惠州学院化学工程系,惠州516007

出　　处：《化工新型材料》2015年第1期62-64,212,共4页New Chemical Materials

基　　金：广东省教育厅科研项目(2013LYM_0088);惠州市科技计划项目(A512.0226)

摘　　要：一种性能优异的生物支架材料无论从物理结构还是化学组成都应尽量仿生物细胞外基质(ECM)。ECM具有纳米级纤维结构,对于细胞的黏附、增殖和分化并最终诱导组织再生起着重要作用,因此,人们致力于研究用合成材料来模仿ECM的物理结构。因此,本研究设计将一类含苹果酸单元的聚丙交酯和聚己内酯嵌段共聚物(P(CL-co-BMD)-bPLLA,(PCM-b-PLLA),在保证聚合物具有半晶质特性的基础上,研究了凝胶化温度,溶剂置换温度对纳米纤维结构形成的影响。这种共聚物含有羧基,可以作偶联短肽之用,为进一步将其应用于神经组织工程提供科学依据。Nanofibrous scaffolds modified with biological peptides,which can mimic the physical and chemical characteristics of an extracellular matrix（ECM）, have been considered good candidate matrices for cell culture in tissue engineering application. A series of semicrystalline block copolymers, specifically pendent carboxyl-containing poly（ε-caprolactone- co-β-malic acid）-block-poly（L-lactide）, were synthesized to fabricate nano-fibrous scaffolds via thermal induced liquid-liquid phase separation process. The impact of gelation temperature and solvent exchange temperature to nano fibril was stud ied. These nanofibrous matrices had design potential to coupling with peptide for tissue engineering.

关 键 词：细胞外基质 嵌段共聚物 凝胶化温度 溶剂置换温度 偶联短肽 

分 类 号：TQ342.87[化学工程—化纤工业]