同型半胱氨酸在肾脏疾病中检测的意义  

A retrospective study on the diagnostic value of serum homocystine in renal diseases

作　　者：高婵[1] 王鸣[1] 费晓[1] 徐群红[1] 赵宁[1] 

机构地区：[1]杭州市第一人民医院肾脏内科,浙江杭州310006

出　　处：《中国现代医生》2015年第3期23-25,28,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2010ZA103)

摘　　要：目的探讨同型半胱氨酸(HCY)的检测对于肾脏疾病的临床意义。方法检测167例肾病患者的血清HCY、尿素氮、肌酐、白蛋白、甲状旁腺素(PTH)、β2微球蛋白,对比HCY与传统肾功能指标,探讨其在肾脏疾病中检测的意义。结果随肾小球滤过率(GFR)降低,HCY水平逐渐增高,当GFR降至90 m L/(min·1.73 m2)以下时,HCY水平较正常增高明显(P<0.05);HCY与肌酐、尿素氮、PTH、β2微球蛋白呈正相关,与Ccr呈负相关。结论 HCY是反映肾脏功能的重要指标,可用于早期肾脏疾病的诊断。Objective To investigate the diagnostic value of serum homocystine （HCY） in renal diseases. Methods Serum HCY, creatinine, urea, albumin, parathyroid hormone （PTH）, β2 microglobulin were measured in 167 patients with renal disease, and the HCY was compared with those traditional index in kidney diseases with the aim to deter-mine the role of HCY played in renal diseases. Results With the decreasing of glomerular filtration rate （GFR）, the serum HCY level increased correspondingly. Compared with normal control group, there were statistically significant differences in the serum HCY when the GFR was below 90 mL/（min·1.73 m2）.HCY was positively correlated with cre-atinine, urea, PTH and β2 microglobulin （P〈0.05）; negatively correlated with endogenous creatinine clearance rate （Ccr） （P〈0.05）. Conclusion HCY may be an important indicator for early diagnosis of the impairment of renal function in renal diseases. It can be used to indicate the degree of severity of renal impairment in patients with nephropathy.

关 键 词：同型半胱氨酸 肾脏疾病 早期诊断 

分 类 号：R692[医药卫生—泌尿科学]