川崎病与支原体感染的相关性研究  

Study on the correlation between Kawasaki disease and mycoplasma pneumomiae

作　　者：汪培勤 饶福光 罗建军[1] 

机构地区：[1]深圳市龙岗区妇幼保健院儿科,广东深圳518172

出　　处：《中国现代医生》2015年第3期41-43,共3页China Modern Doctor

摘　　要：目的：研究川崎病（Kawasaki disease，KD）与支原体感染（Mycoplasma pneumomiae，MP）的相关性。方法回顾性分析2012年3月～2014年2月于我院被确诊为KD的84例患儿的病历资料，其中按照患者是否有支原体感染分为观察组和对照组。观察组KD患者为有支原体感染（43例），对照组KD患者无MP感染（41例）。对两组患者分别进行血白细胞计数（WBC）、超敏C反应蛋白（CRP）、红细胞沉降率（ESR）、血红蛋白（HB）以及血小板计数（PLT）的检测和分析。对两组患者是否存在冠脉损伤进行分析比较。结果观察组无冠脉损伤者占34.9%（15/43），明显低于对照组的58.5%（24/41），观察组冠脉损伤者占比65.1%（28/43），显著高于对照组的41.5%（17/41），差异均有统计学意义（P＜0.05）；观察组的CRP指标水平为（68.9＆#177;14.7）mg/L，明显高于对照组的（52.8＆#177;8.2）mg/L，观察组的ESR指标水平为（42.6＆#177;15.9）mm/h，显著高于对照组的（21.6＆#177;6.1）mm/h，差异均有统计学意义（P＜0.05）。结论 MP感染为KD的病因之一，MP感染与患者冠脉损伤呈正相关，MP感染引起的免疫介导损伤和炎症反应是发生KD的重要途径。Objective To invetigate the correlation between Kawasaki disease （KD） and mycoplasma pneumomiae （MP）. Methods The medical records of 84 children diagnosed as KD in our hospital from March 2012 to February 2014 were retrospectively analyzed, and according to whether with mycoplasma infection or not ,they were divided into observation group and control group. The observation group included 43 cases with mycoplasma infection, and the control group in-cluded 41 KD patients without MP infection. White blood cell count （WBC）, high sensitive C reactive protein （CRP）, erythrocyte sedimentation rate （ESR）, hemoglobin （HB）, platelet count （PLT） were detected and analyzed in two groups. Patients of the two groups were compared in whether the existence of coronary artery lesions. Results Patients of the observation group without coronary artery injury accounted for 34.9%（15/43）, significantly lower than that of the con trol group 58.5%（24/41）, and the observation group with coronary lesions accounted for 65.1%（28/43）, significantly higher than that of the control group 41.5%（17/41）. The differences were statistically significant （P〈0.05）; CRP of the observation group was （68.9＆#177;14.7） mg/L, significantly higher than that of the control group （52.8＆#177;8.2） mg/L, and ESR of the observation group was （42.6 ＆#177;15.9） mm/h, significantly higher than that of the control group （21.6 ＆#177;6.1） mm/h. The differences were statistically significant （P〈0.05）. Conclusion MP is one of the causes of KD and has positive corre-lation with coronary artery injury of patients. The injury and inflammation reaction mediated by autoimmune reaction caused by MP is an important way to KD.

关 键 词：川崎病 支原体感染 冠脉损伤 相关性 

分 类 号：R725.4[医药卫生—儿科]