Bcl-2、Bax介导肺微血管内皮细胞凋亡与神经源性肺水肿  

作　　者：刘雁[1] 彭忠田[1] 

机构地区：[1]南华大学附属第一临床学院,湖南衡阳421001

出　　处：《医学美学美容（中旬刊）》2015年第1期24-24,共1页

摘　　要：近几年来手足口病在全球的发病率非常高，重症手足口病并发神经源性肺水肿（neumgenlc pulmonaryed ema，NPE）起病急，病情发展快，病死率较高。NPE与肺微血管内蛊和脾迥亡市关。Bel-2和Box是Bcl-2家族中与细胞凋亡关系密切的两种基因，前者为抗凋亡基因，后者为促凋亡基因。Bcl-2、Bax的表达可能与NPE的发病有关。In recent years, the incidence rate of hand foot and mouth disease is very high in the global, severe hand foot and mouth disease could be complicated by neurogenic pulmo- nary edema had onset nasty, illness development quickly, high fatality rate. NPE is associated with apoptosis of pulmonary microvaseular endothelial cell. Bel - 2 gone and Bax gene is closely as- sociated with apoptosis in the Bcl - 2 family , the former for antiapoptotic genes, the latter to promote apoptosis gene. the expression of Bcl - 2 gene and Bax gene may be associated with the onset of NPE.

关 键 词：手足口病 神经源性肺水肿 肺微血管内皮细胞 BCL-2 BAX 

分 类 号：R762.21[医药卫生—耳鼻咽喉科]