厦门地区62例染色体随体区变异在不良孕产中的临床观察与探讨  

Chromosome clinical observation and discussion variation in adverse pregnancy

作　　者：刘芳[1] 史彩虹[1] 王厚照[1] 周友泉[1] 

机构地区：[1]解放军第174医院检验科遗传室,福建厦门361003

出　　处：《中国优生与遗传杂志》2015年第1期23-24,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 探讨染色体随体区变异在不良孕产中的可能作用。方法 对2009年8月-2013年10月来我院就诊的生殖异常患者,取外周血淋巴细胞培养,并经G显带、C显带及染色体图象分析仪分析。结果 在对3696例患者中,检出62例随体区变异（占1.7%）,其中随体增加（ps＋）28例,占随体区变异的45.1%;双随体（pss）12例,占随体区变异的19.3%;随体柄增加（pstk＋）6例,占随体区变异的9.8%;随体区异染色质增加（ph＋）4例,占随体区变异的6.5%;随体缺失（ps-）10例,占随体区变异的16.1%;Y染色体长臂上的随体（Yqs）2例,占随体区变异的3.2%。结论 在不良孕产患者中应高度关注染色体随体区变异。Objective： To investigate the possible role in adverse pregnancy chromosome satellite variation. August 2009 to October 2013, our hospital reproductive abnormalities in patients with peripheral blood lymphocyte culture and G-banding, C significantly with chromosome image analyzer. Results： of the 3696 cases were detected in 62 cases with the body region variation （1.7%） . Increased with the body （ps ＋） in 28 cases, with the body region variation of 45.1%, 12 cases of double with the body （pss） , with the body region variation of 19.3%, with the body handle increased （pstk ＋） in 6 cases, accounting for minisatellite area variation of 9.8%, with the body region different chromatin increased （ph ＋） 4 cases, with the body region of variation of 6.5%, with the body of missing 10 cases of （ps-） , with the body region variation of 16.1%, Y-chromosome long arm with the body （Yqs） 2 cases, accounting for 3.2% of the variation with the body region. Conclusion： In patients with adverse pregnancy should be highly concerned chromosome variation with the body region.

关 键 词：不良孕产 随体区 变异 

分 类 号：R714.2[医药卫生—妇产科学]