LKB1在冠心病患者的表达及临床意义  

Expression level and clinical significance of LKB1 in coronary artery disease

作　　者：赖绍斌 赵冬华[1] 邓斌[1] 苏良献[1] 张艳红[1] 何慧娟[1] 伦爱美[1] 吴峻[3] 

机构地区：[1]广东肇庆市第一人民医院心内科,肇庆526040 [2]广州医科大学 [3]广州医科大学附属第一医院心内科,广州510120

出　　处：《新医学》2015年第1期16-19,共4页Journal of New Medicine

基　　金：广东省科技计划项目资助(2011B080701073)

摘　　要：目的通过检测不同冠状动脉病变程度患者的血清肝脏激酶B1(LKB1)水平,探讨其在冠状动脉粥样硬化性心脏病(冠心病)的临床意义。方法 30例AMI患者为A组,选择同期性别、年龄匹配的冠状动脉狭窄患者30例(B组)及冠状动脉正常患者30名(C组)作为对照。所有患者均行冠状动脉造影检查,于术前30 mim抽取外周血,用ELISA法测定LKB1血清浓度,并比较各组的差异。结果与C组[(4.32±1.68)ng/ml]比较,A组[(3.13±1.15)ng/ml]和B组[(3.41±0.88)ng/ml]LKB1水平均较低(P分别为0.001和0.006)。A组与B组间LKB1水平比较差异无统计学意义(P=0.369)。结论 LKB1在冠心病患者明显降低,可能可以作为新的无创性检测冠心病的生物标记。Objective To compare the differences of serum liver kinase B1 （LKB1）in patients with varying degree of coronary artery disease and explore its clinical significance for coronary heart disease.Methods Thirty patients with acute myocardial infarction （AMI）were assigned to group A.Thirty age-and sex-matched subjects with coronary artery stenosis were recruited in group B and 30 subjects with normal coronary artery were recruited in group C.All participants underwent coronary angiography.At preoperative 30 min,periphery blood sample was collected.The serum LKB1 was determined using ELISA and statistically compared a-mong three groups.Results The serum LKB1 in group A was （3.13 ±1.15）ng/ml and （3.41 ±0.88）ng/ml in group B,significantly lower compared with that in group C （P =0.001 and P =0.006）.The serum LKB1 did not significantly differ between groups A and B （P =0.369）.Conclusions The level of LKB1 is significantly decreased in patients with coronary artery disease,which may serve as a novel non-invasive bio-marker of diagnosing coronary artery disease.

关 键 词：肝脏激酶B1 冠状动脉粥样硬化性心脏病 生物标记 酶联免疫吸附试验 

分 类 号：R541.4[医药卫生—心血管疾病]