5种促排卵方案对子宫腔内人工授精妊娠结局的影响  

Influence of different ovarian stimulation protocols on the outcome of intrauterine insemination

作　　者：叶艳娜[1,2] 陈宇栋[3] 贾佳[1] 吴泽璇 文娅[1] 李予[1] 杨冬梓[1] 张清学[1] 

机构地区：[1]中山大学孙逸仙纪念医院生殖中心,广州510120 [2]广东省东莞卫生学校 [3]河北医科大学第二医院东院区妇二科,石家庄050000

出　　处：《新医学》2015年第1期40-44,共5页Journal of New Medicine

摘　　要：目的比较不同促排卵方案对子宫腔内人工授精妊娠结局的影响。方法收集行子宫腔内人工授精助孕的303对不孕夫妇482周期的临床资料,根据促排卵方案不同分为6组,分别为自然周期组、氯米芬组、来曲唑组、促性腺激素(HMG)组、氯米芬联合HMG组和来曲唑联合HMG组,比较6组的妊娠结局。结果 HCG注射日,HMG组患者的子宫内膜最厚,氯米芬组和来曲唑组的子宫内膜较薄。氯米芬联合HMG组和来曲唑联合HMG组临床妊娠率分别为26%(12/46)和29%(9/31),均明显高于自然周期组(10%,16/156)和来曲唑组(6%,3/55),P均<0.008。各组的自然流产率和多胎妊娠率组间比较差异均无统计学意义(P均>0.05)。结论氯米芬联合HMG或来曲唑联合HMG联合用药促排卵方案可明显提高子宫腔内人工授精的临床妊娠率。Objective To compare the effects of different ovarian stimulation protocols on the clinical outcome of intrauterine insemination （IUI）.Methods Clinical data of 303 infertile couples were collected during 482 IUI cycles.According to different ovarian stimulation protocols,all patients were assigned into six groups：NC （natural cycle）,CC （clomiphene citrate）,LE （letrozole）,HMG （human menopausal gonadotro-phin）,（CC ＋HMG）and （LE ＋HMG）groups.Results At HCG injection day,the endometrial of patients in HMG group were the thickest,but thinner in CC and LE group.The pregnancy rates of （CC ＋HMG）and （LE ＋HMG）groups were 26% （12 /46）and 29% （9 /31）,significantly higher than those of NC （10%,16 /156）and LE groups （6%,3 /55）（all P 〈0.008）.No statistical significance was observed among different groups in the rates of spontaneous abortion rate and multiple pregnancy（all P 〉0.05）.Conclusion Com-bined ovarian stimulation protocols,such as CC ＋HMG or LE ＋HMG,could significantly increase the clinical pregnancy rate of IUI.

关 键 词：子宫腔内人工授精 不同促排卵方案 临床妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]