犬皮下注射麻保沙星生物利用度的研究  

Study on Bioavailability of Marbofloxacin after Subcutaneous Administrations in Dogs

作　　者：阮祥春[1,2] 季辉[2] 彭麟[2] 高修歌[2] 张冠军[2] 江善祥[2] 

机构地区：[1]安徽农业大学动物科技学院,安徽合肥230036 [2]南京农业大学动物医学院,江苏南京210095

出　　处：《动物医学进展》2015年第2期58-61,共4页Progress In Veterinary Medicine

摘　　要：为了研究麻保沙星在犬皮下给药的生物利用度,将18只犬随机分成2组,按照2mg/kg分别皮下注射或静脉注射麻保沙星后,采血待检,2周后两组交叉给药后,采血。分别在药物注射后5、10、15、30、45min,1、1.5、2,4、6,8、12、24、36、72h时采集血液。血浆通过高效液相色谱法检测药物浓度,用3P97药代动力学软件进行分析。麻保沙星皮下注射的平均药代动力学参数为:t1/2ka=0.19±0.08h;t1/2ke=7.21±1.88h;tmax=0.97±0.29h;Cmax=1.13±0.17μg/mL;AUC=13.13±4.24μg·h/mL;CL=0.17±0.05L/h;V/F=1.63±0.24L/kg。犬皮下注射麻保沙星的绝对生物利用度为66.7%,皮下注射能迅速被吸收且有较高的组织渗透性。In order to study on bioavailability of marbofloxacin after subsutaneous administration in dogs, 18 dogs were divided into two groups randomly, subcutaneously and intravenously administrated with 2 mg/kg bodyweight of marbofloxacin, then, cross administrated after 2 weeks. The blood was collected at 5, 10, 15, 30, 45 min, 1, 1.5, 2, 4, 6, 8, 12, 24, 36, 72 h. Drug concentrations in plasma were de termined by high performance liquid chromatography and the data were analyzed by 3P97 pharmacokinetics software. Mean pharmacokinetic parameters after subcutaneous administration were as following, t1/2ka = 0.19±0.08 h; t1/2ke = 7. 21±1. 88 h; tmax=0. 97±0. 29 h; Cmax = 1. 13±0. 17 μg/mL; AUC=13. 13± 4.24 μg · h/mL; V/F=1. 63±0.24 L/kg and CL=0. 17±0.05 L/h. Bioavailability of marbofloxacin was about 66. 7% in dogs after subcutaneous administration, and marbofloxacin was rapidly absorbed after subcutaneous administration, and had good tissue penetration.

关 键 词：麻保沙星 氟喹诺酮类 生物利用度 高效液相色谱 狗 皮下注射 

分 类 号：S859.796[农业科学—临床兽医学] S858.292[农业科学—兽医学]