芥子中芥子碱类和硫代葡萄糖苷类成分化学稳定性和质量评价研究进展  

Advances in study on chemical components, stability, and quality evaluation of sinapinoids and glucosinolates in Sinapis Semen

作　　者：张青山[1,2] 王卓[1,2] 孔铭[1,3,4] 刘丽芳[2] 李松林[1,3,4] 

机构地区：[1]南京中医药大学附属中西医结合医院中药质量研究室,江苏南京210028 [2]中国药科大学天然药物活性组分与药效国家重点实验室,江苏南京210009 [3]江苏省中医药研究院 [4]中国中医科学院江苏分院中药代谢组研究室,江苏南京210028

出　　处：《中草药》2015年第1期148-156,共9页Chinese Traditional and Herbal Drugs

基　　金：国家高技术研究发展计划资助项目(“863”计划)(2014AA022204)

摘　　要：芥子中主要化学成分为硫代葡萄糖苷类和芥子碱类。芥子碱类成分具有抗氧化、抗雄性激素、缓慢降压等多种药理活性;硫代葡萄糖苷类成分及其降解产物具镇咳平喘、抗氧化、抗癌、抗菌等功效。综述了芥子中硫代葡萄糖苷类和芥子碱类成分的化学组成、稳定性和质量控制方法的最新研究进展,以期对芥子药材及其相关产品的质量控制和合理开发利用提供科学指导。Sinapinoids and glucosinolates are the main chemical components in Sinapis Semen. Sinapinoids have significant biological activities, such as anti-oxidant, anti-androgen, lowering the blood pressure, and so on. Glucosinolates and their degradation products are known for its biological functions such as fungicidal, bactericidal, and in the treatment of cancer and cough. The latest progress on the chemical components, stability, and quality evaluation of sinapinoids and glucosinolates in Sinapis Semen is reviewed, which could provide some scientific guidance for the quality control and exploration of Sinapis Semen and its related products.

关 键 词：芥子 硫代葡萄糖苷类 芥子碱类 稳定性 质量评价 

分 类 号：R284[医药卫生—中药学]