丙型肝炎患者白细胞介素-2受体和肝功能损伤的相关研究  

A correlated study on serum SIL-2R and liver injury in patients with hepatitis C

作　　者：何浩明[1] 冯岚[2] 田小平[1] 谢晓东[1] 

机构地区：[1]江苏省连云港市第一人民医院临床免疫研究室,222002 [2]江苏省连云港市第四人民医院传染科,222002

出　　处：《淮海医药》2002年第5期355-356,共2页Journal of Huaihai Medicine

摘　　要：目的　探讨血清可溶性白细胞介素 - 2受体 (SIL- 2 R)、T淋巴细胞亚群等在丙型肝炎病毒感染中的作用。方法　应用双抗体夹心 EL ISA法和单克隆抗体测定法对 5 8例丙型肝炎患者进行了血清 SIL - 2 R和 T淋巴细胞亚群等进行相关研究 ,并以正常人 35名作对照。结果　丙型肝炎患者血清 SIL- 2 R水平显著地高于正常人组(P<0 .0 0 1) ,尤以肝硬变组明显。SIL - 2 R水平与 T细胞亚群中 CD8细胞比例 ,与 AL T密切相关。结论　检测丙型肝炎患者血清中 SIL- 2 R、T淋巴细胞亚群等水平可做为丙肝患者病情变化、预后判断及临床用药的监测指标。Objective The explore the effect of serum SIL-2R in patients infected with hepatitis C virus(HCV).Methods Level of serum SIL-2R was detected with enzyme linked immunosorbent assay(ELISA)and T-Lymphocyte subgroups by monoclone antibody in 58 cases of hepatitis C and 35 normal controls.Results Serum level of SIL-2R was obsviously higher in patients with hepatitic C,esperciatly in patients with liver cirrhosis than those in normal controls(P<0.01).There was sighificantly positve correlation between serum levels of SIL-2R,T-lymphocyte subgroup and CD4/CD8 ratio and ALT.Conclusion Detection of serum SIL-2R level might be one of the important parameters for clinical evaluation in pa-tients with hepatities C.

关 键 词：丙型肝炎 肝功能 白细胞介素-2受体 T淋巴细胞亚群 单克隆抗体测定法 双抗体夹心ELISA法 

分 类 号：R512.63[医药卫生—内科学]