2型糖尿病性血管病患者可溶性细胞粘附分子-1水平的变化及相关性研究  

Study of souble intercellular adhesion molecule-1 level in patients with type 2 diabetic angiopathy

作　　者：吴岩[1] 黄慧建[1] 田小平[1] 

机构地区：[1]江苏省连云港市第一人民医院内分泌科,222002

出　　处：《淮海医药》2002年第5期372-373,共2页Journal of Huaihai Medicine

摘　　要：目的　探讨 2型糖尿病性血管病患者血清 SVCAM- 1水平的变化及意义。方法　应用 EL ISA法检测了 5 7例 2型糖尿病血管病患者血清 SVCAM- 1水平 ,并与 35名正常健康人作对照。并将其结果与空腹血糖、糖化血红蛋白、尿微量白蛋白进行相关分析。结果　 2型糖尿病性血管病患者血清中 SVCAM- 1水平显著高于正常人组 (P<0 .0 1) ,且与空腹血糖、糖化血红蛋白、尿微量白蛋白等密切相关。结论　血清 SVCAM- 1含量的升高可能参与 2型糖尿病性血管病的发生、发展过程。Objective To study the change and significance of soluble intercellular adhesion molecule-1(SVCAM-1) level in patients with type 2 diabetic angiopathy.Methods The cencentration of SVCAM in 57 cases of type 2 diabetic angiopathy and 35 normal controls were detected with ELISA and combined with the levels of fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),urine microalbumin(MAlb) for correlation analysis.Results SVCAM-1 level in patients with type-2 diabetic angiopathy was higher than those in normal controls(P<0.01)and closely related to the levels of FBG,HbAlc,MAlb(P<0.01).Conclusion Higher SVCAM-1 level may be contribute to the occurrence and development of type 2 diabetic angiopathy.

关 键 词：2型糖尿病性血管病 可溶性血管细胞粘附分子-1 血糖 糖化血红蛋白 尿微量白蛋白 

分 类 号：R587.2[医药卫生—内分泌]