人巨细胞病毒潜伏感染相关基因研究进展  

Advances in the study of human cytomegalovirus latency-associated transcripts

作　　者：浮苗[1,2] 田可港[1,3] 郑晓群[1,4] 

机构地区：[1]温州医科大学附属第二医院,育英儿童医院,浙江温州325027 [2]金华市中心医院,浙江金华321000 [3]青岛市中心医院,山东青岛266000 [4]温州医科大学检验医学院,浙江温州325035

出　　处：《中国病原生物学杂志》2014年第12期1134-1138,共5页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.81071365);浙江省自然科学基金项目(No.LY13H190006)

摘　　要：人巨细胞病毒(HCMV)在人群中感染非常普遍,在免疫功能正常的个体,HCMV初次感染大多数能够被宿主的免疫系统有效清除,少部分通过建立长期的潜伏感染生存下来。HCMV基因组庞大,表达许多病毒基因产物,其中一部分可能促进病毒潜伏在宿主细胞中。目前对于HCMV在宿主体内潜伏感染的机制及相关基因的表达知之甚少,本文将对近年来有关HCMV潜伏感染时相关病毒基因的表达及功能研究作一综述。Human cytomegalovirus（HCMV）is a common,opportunistic pathogen.Following primary productive infection the virus is not completely eliminated from the immunocompetent host,but instead establishes a lifelong latent infection without detectable virus production.The HCMV genome is large and has the potential to express many gene products,and some of these may facilitate viral latency in the human host.Despite decades of research,we have little more than a cursory understanding of the molecular basis of HCMV latency and the expression of CMV latency-associated transcripts.This article will cover several aspects of HCMV latency,with a focus on current understanding of viral gene expression and functions during this phase of infection.

关 键 词：人巨细胞病毒 潜伏感染 病毒基因 综述 

分 类 号：R373.11[医药卫生—病原生物学]