丙烯腈对大鼠神经行为功能影响的研究  

Effects of Acrylonitrile Exposure on Neurobehavioral Function in Rats

作　　者：金焕荣[1] 谢怀江[2] 王任群[1] 赵肃[1] 

机构地区：[1]沈阳医学院劳动卫生教研室,辽宁沈阳110034 [2]沈阳军区后勤部军事医学研究所,辽宁沈阳110034

出　　处：《工业卫生与职业病》2002年第4期209-211,共3页Industrial Health and Occupational Diseases

摘　　要：目的　通过丙烯腈染毒大鼠的自发活动性、转棒实验、步下法及方位水迷宫测试 ,探讨丙烯腈对神经行为功能的影响。方法　大鼠腹腔注射染毒 ,每日 1次 ,连续 30d ,单次染毒剂量分别为 3 2 ,6 5 ,15mg/kg,染毒结束后进行神经行为功能测试。结果　丙烯腈各染毒组的转棒实验与对照组比较 ,差异无显著性 ,说明大鼠的运动协调功能未受影响 ;各染毒组的步下法测试及水迷宫测试的结果与对照组相比 ,差异也无显著性 ,说明大鼠的学习、记忆功能未受损害。而且染毒组自发活动性测试结果与对照组相比 ,差异也无显著性。结论　在本实验的染毒时间和染毒剂量范围条件下 ,丙烯腈对大鼠神经行为功能无明显影响。Objective To study effects of acrylonitrile exposure on neurobehavioral function in rats.Methods The exposure of rat groups was made by daily intraperitoneal injection with acrylonitrile dosage of 3\^2,6\^5 and 13 mg/kg respectively for 30 days.The neurobehavioral function including spontaneous activity measurement,rotarod test,spatial water maze and step\|down test was observed.Results No significant difference was observed in rotarod test between exposed groups and the control group.Motor coordinate dysfunction of the exposed rats was not changed.No significant difference in spontaneous activity,step\|down test and spatial water maze was found.The learning and memory abilities also had no change.Conclusions No neurobehavioral damage had been observed in rats at acrylonitril dosage of 13 mg/kg.

关 键 词：神经毒性 丙烯腈 神经行为 自发活动性 转棒实验 步下法 方位水迷宫 

分 类 号：R135.1[医药卫生—劳动卫生]