胰岛素强化治疗对严重创伤患者炎症介质和外周血核转录因子κB的影响  

The effects of intensive insulin therapy on the inflammatory mediators and peripheral blood nuclear transcription factor(NF-κB)in severe trauma patients

作　　者：周虹[1] 马俊勋[2] 高诗博[2] 刘阳[2] 姚咏明[2] 赵晓东[2] 

机构地区：[1]解放军总后勤部司令部管理保障局第一门诊部,北京100842 [2]解放军总医院第一附属医院急救部

出　　处：《临床急诊杂志》2014年第12期709-712,共4页Journal of Clinical Emergency

基　　金：国家重点基础研究发展规划(973)项目(No:2005CB522602)

摘　　要：目的:探讨胰岛素强化治疗对临床严重创伤患者应激性高血糖的炎症介质、外周血核转录因子κB的影响。方法:分别通过ELISA和PCR检测TNF-α、IL-6和NF-κB。结果:胰岛素强化治疗能降低血清炎症介质TNF-α、IL-6水平,能显著降低NF-κB表达。结论:胰岛素强化治疗可有效下调创伤后炎症介质水平,降低NF-κB的转录水平。Objective：To explore the effects of intensive insulin therapy on the inflammatory mediators and peripheral blood nuclear transcription factor in severe trauma patients with stress hyperglycemia.Method：TNF-α,IL-6and NF-κB activity were detected by ELISA and PCR.Result：In the clinical experimental study,TNF-αand IL-6in the serum levels were decreased.The intensive insulin therapy can significantly decrease the NF kappa B expression.Conclusion：Intensive insulin therapy can effectively lower the post-traumatic inflammatory mediators levels and reduce the NF kappa B transcription level.

关 键 词：严重创伤 胰岛素强化治疗 炎症介质 NF-ΚB 

分 类 号：R641[医药卫生—外科学]