头皮记录的频率跟随响应的回顾和现状  

Brief Review of Scalp-recorded Frequency-following Response

作　　者：张骁晨 宫琴[2] 

机构地区：[1]清华大学医学院,北京100084 [2]清华大学深圳研究生院生物医学工程研究中心,广东深圳518055

出　　处：《生命科学仪器》2014年第6期7-15,共9页Life Science Instruments

基　　金：国家自然科学基金(No.61271133);教育部(高等学校博士学科点专项科研)博导基金(No.20120002110054);清华信息科学与技术国家实验室(筹)学科交叉基金;深圳市科技计划项目(No.JCYJ20140827160046745)

摘　　要：频率跟随响应是一种持续周期性刺激声诱发产生的听觉脑干稳态响应,其产生于听觉脑干中的多个位置,它反映了听觉脑干神经元对刺激声中的周期性成分的锁相活动。典型的由纯音或复合音诱发的频率跟随响应,其频谱在基频及其倍频处均有谱峰,而其能量集中在基频附近,双频率复合音诱发的响应中还包含畸变产物。频率跟随响应可能包含与音调感知有关的信息,因而成为听觉脑干层面的语音或音调编码和可塑性的研究工具。本文就频率跟随响应的产生位置、信号特点及其对听觉脑干的语音和音调编码的反映等方面进行了综述。Frequency-following response （FFR） is a sustained brainstem potential which might be attributed to multiple generators in auditory brainstem, therefore FFR is regarded as reflection of neural phase-locking activity in auditory brainstem to the periodic stimulus components. Typical FFRs evoked by pure tones or complex tones display spectral peaks at fundamental frequency and harmonics as well, but the peak at ftmdamental frequency is predominant. FFRs evoked by two-tone stimuli also contain distortion product. FFR might bear pitch-relevant information, thus enabling itself to be used as a tool for brainstem-level exploration in auditory speech and pitch coding or plasticity. This paper briefly reviewed several aspects of FFR, such as its neural generators, its response characteristics and its reflection of speech or pitch perception.

关 键 词：频率跟随响应 产生位置 畸变产物 音调感知 可塑性 

分 类 号：TN82[电子电信—信息与通信工程]