职业性哮喘患者的交感皮肤反应变化及临床意义  

Sympathetic Skin Response in Patients with Occupational Asthma and Related Clinical Implication

作　　者：李丹丹[1,2] 宋莉[1] 石冬梅[1] 潘秀斌 丰宏林[2] 

机构地区：[1]黑龙江省中毒抢救治疗中心内三科,黑龙江150010 [2]哈尔滨医科大学附属第一医院神经内科,黑龙江150001

出　　处：《环境与职业医学》2015年第1期61-64,共4页Journal of Environmental and Occupational Medicine

摘　　要：[目的]对职业性哮喘患者进行交感皮肤反应测定,探讨其交感神经损害与职业性哮喘程度分级及病程的关系。[方法]根据职业性哮喘分级和病程将146例职业性哮喘患者分为轻度<5年组(36例)、轻度≥5年组(38例);中重度<5年组(34例)和中重度≥5年组(38例),以38例同工厂健康工人为对照组。测定该5组(患者4组、对照1组)人群的交感皮肤反应(SSR)各项指标(上肢潜伏期、下肢潜伏期、上肢波幅、下肢波幅)并分析比较。[结果]各病例组患者中SSR异常者占54.0%;对照组SSR异常者占21.0%。各病例组SSR上、下肢潜伏期较对照组延长,差异均有统计学意义(P<0.05);各病例组SSR上、下肢波幅较对照组降低,差异均有统计学意义(P<0.05);除中重度<5年组和中重度≥5年组下肢波幅指标外,各病例组和对照组SSR各指标(上肢潜伏期、下肢潜伏期、上肢波幅、下肢波幅)两两比较,差异均有统计学意义(P<0.05)。[结论]职业性哮喘患者可能存在一定程度的交感神经功能损害,可随哮喘程度分级加重、病程延长而进一步加重。[Objective ]To explore the association of sympathetic nerve damage with occupational asthma （OA） severity categories and courses by measuring the sympathetic skin response （SSR） in OA patients. [ Methods ] According to OA severity classification and course, 146 patients were divided into four groups, including Group 1 with mild ＋ 〈5 years （n=36）, Group 2 with mild ＋ ≥ 5 years （n=38）, Group 3 with moderate-sever ＋ 〈5 years （n=34）, and Group 4 with moderate-sever ＋ ≥ 5 years （n=38）. Another 38 healthy workers in the same factory were selected as the control group. All the subjects received SSR tests to compare latencies in upper and lower limbs as well as amplitudes in upper and lower limbs. [ Results ] The SSR abnormality was found in 54.0% of the OA patients, compared with 21.0% in the control group. Longer SSR latencies for upper and lower limbs were found in the four OA groups than those in the control group （P 〈 0.05）; while lower SSR amplitudes for upper and lower limbs were found in the four OA groups than ~those in the control group （P 〈 0.05）. Except the lower limbs amplitude of Group 3 and 4, the paired differences in SSR indicators including upper limbs latency, lower limbs latency, upper limbs amplitude, and lower limbs amplitude between the four OA groups and the control group were statistically significant （P 〈 0.05）. [ Conclusion ] Sympathetic nerve dysfunction could occur in the OA patients and be aggravated by the course and severity of the illness.

关 键 词：职业性哮喘 交感皮肤反应 波幅 潜伏期 临床意义 

分 类 号：R135[医药卫生—劳动卫生]