T2DM患者夜间低氧与血糖的关系及无创通气治疗对OWD患者昼夜血糖的影响  

The relationship between nocturnal oxygen desaturation and blood sugar level and noninvasive ventilation therapy effect on the blood sugar level of OWD patients

作　　者：何忠明[1] 陈龙[1] 石娟[1] 阿力旦.毛达汗 雷清生[1] 韩芳[2] 

机构地区：[1]新疆克拉玛依市中心医院呼吸科,新疆克拉玛依834000 [2]北京大学人民医院呼吸与危重症科,北京100044

出　　处：《新疆医科大学学报》2015年第2期197-199,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81360016);新疆克拉玛依市科技项目(SK 2011-45)

摘　　要：目的探讨2型糖尿病(T2DM)患者夜间低氧与血糖的关系及无创通气治疗对2型糖尿病合并睡眠呼吸暂停低通气综合征(OWD)患者昼夜血糖的影响。方法对750例T2DM打鼾患者进行夜间脉搏-氧饱和度监测,根据夜间出现低氧情况分为夜间低氧组(484例)与无夜间低氧组(266例),对两组患者年龄、体质指数(BMI)、颈围、腹围、空腹血糖(FBG)进行分析,并对7例OWD患者进行睡眠监测、脉搏血氧监测及96 h动态血糖监测(CGMS),呼吸机无创通气治疗48 h前后,比较OWD患者昼夜血糖变化。结果夜间低氧组和夜间无低氧组BMI分别为(27.2±4.8)、(25.5±3.0)kg/m2,颈围分别为(36.7±3.8)、(35.7±3.0)cm,腰围分别为(94.3±11.5)、(89.1±11.1)cm,空腹血糖分别为(6.9±2.4)、(6.5±2.0)mol/L,组间差异均有统计学意义(P<0.05)。7例OWD患者无创通气治疗前后,昼夜动态动态血糖水平差异有统计学意义(P<0.05)。结论 T2DM患者空腹血糖与夜间低氧相关,无创通气治疗可以降低OWD患者昼夜血糖水平。Objective To study the relationship of nocturnal oxygen desaturation and blood sugar level,and the effects noninvasive ventilation（NIV）therapy on the blood sugar level of OWD.Methods 750 snoring patients were received the nocturnal oxygen desaturation test.According the test results,the 750 patients were divided into：the normal and the low nocturnal oxygen desaturation group,to compare the BMI,neck circumference,abdominal circumference and the blood sugar.The blood sugar level were measured and compared before and after the nocturnal NIV therapy.Results The results showed：（1）There were sig-nificant differences between the normal and the low nocturnal oxygen desaturation group on the body mass [（27.2±4.8）kg/m^2 vs.（25.5±3.9）kg/m^2 ],neck circumference [（36.7±3.8）cm vs.（35.7±3.0）cm],ab-dominal circumference [（94.3±11.5）cm vs.（89.1±11.1）cm]and blood sugar [（6.9±2.4）mmol/L vs. （6.5±2.0）mmol/L]respectively;（2）The blood sugar level of the OWD patient were significantly de-creased after the nocturnal NIV therapy （P 〈0.05 vs none therapy）.Conclusion The nocturnal oxygen desaturation is closely related to the blood sugar level of Type 2 diabetes mellitus patients,and the short-term NIV therapy can reduce the blood sugar level of OWD patients.

关 键 词：睡眠呼吸暂停低通气综合征 2型糖尿病 无创通气 

分 类 号：R563[医药卫生—呼吸系统]