微血管中磁性药物纳米粒子输运磁场分布的研究  

Research on Magnetic Field of Magnetic Nanoparticle Transport in Microvessel

作　　者：曹洁洁[1] 

机构地区：[1]东南大学机械工程学院,江苏南京210000

出　　处：《机械制造与自动化》2015年第1期64-67,共4页Machine Building & Automation

摘　　要：磁场是磁性药物纳米粒子在微血管中输运的主要驱动力。在磁性药物靶向治疗系统中,磁粒子在磁场中被磁化,外磁场将对其产生吸引力,使其向磁场范围运动;同时被磁化的磁粒子之间将产生有效偶极子场,即附加磁场。考虑外磁场以及附加磁场的作用,推导出外磁场、附加磁场、外磁场力和附加磁场力的方程,通过数值模拟分析,讨论了磁场和磁力在微血管中的分布规律以及外磁介质参数对磁场强度和磁力的影响作用。研究结果显示,圆柱型永磁体能够产生较合适磁场强度和磁场梯度,以获得理想的靶向效果。Magnetic field is a major power source of magnetic nanoparticle transport in microvessel. In the magnetic drug targeting therapy system,the magnetic nanoparticles are magnetized in the magnetic field and attracted within the range of the magnetic field.At the same time,an induced dipole-dipole interaction between the magnetic nanoparticles,namely the modifield magnetic field,come into existence. Considering both external and modifield magnetic fields,this paper simulates the distribution of the magnetic field and magnetic force and discusses their effects on the magnetic nanoparticle transport. Results show that the magnetic force is bigger as the distance between magnet and blood vessel is nearer.

关 键 词：磁性药物 纳米粒子 圆柱型永磁体 外磁场 附加磁场 

分 类 号：TP391.9[自动化与计算机技术—计算机应用技术]