重组人脑利钠肽治疗急性心力衰竭临床观察  

The clinical observation of recombinant human brain natriuretic peptide in treatment of acute heart failure

作　　者：肖勇强[1] 黄建清[2] 

机构地区：[1]自贡市第一人民医院心血管内科,四川自贡643000 [2]自贡市第二人民医院内科,四川自贡643000

出　　处：《实用临床医药杂志》2014年第E02期74-76,共3页Journal of Clinical Medicine in Practice

摘　　要：目的观察重组人脑利钠肽（rhBNP）治疗急性心力衰竭（AHF）疗效。方法60例急性心力衰竭患者随机分为对照组及治疗组，各30例。2组均给予常规治疗，治疗组在常规治疗基础上加用rhBNP。治疗72h及3月后分别检测心脏每搏输出量（SV），心输出量（CO），及左室射血分数（LVEF），左室舒张末期内径（LVEDD）。结果治疗组总有效率93．3（28／30），对照组为70％（21／30），2组差异显著（P〈O．05）；治疗组患者各项指标改善均显著优于对照组（P〈0．05或P〈0．01）。结论针对AHF患者，rhBNP治疗AHF患者近期疗效显著，能有效改善患者心脏功能。Objective To obsearve the effects of recombinant human brain natriuretic peptide （rhBNP） for acute heart failure （AHF）. Methods A total of 60 patients with acute heart failure were randomly divided into treatment group （n = 30） and control group （n = 30）. The two groups were given conventional treatment, and treatment group with additional administration of rhBNP. The stroke volume （ SV）, cardiac output （CO） ,left ventricular ejection fraction （LVEF） and left ventricular enddiastolic diameter （LVEDD） were observed after 72 hours and 3 months. Results The overall response rate was 93.3% in treatment group and 70% in control group（P 〈 0.05 ） o indexs mentioned above in the treatment group were improved withbetter outcomes than those of control group（P 〈 0. 05, P 〈 0. 01 ）. Conclusion rhBNP is effective to cardiac function of patients with AHF

关 键 词：脑利钠肽 心力衰竭 血管紧张素 

分 类 号：R541.61[医药卫生—心血管疾病]