血清S100B蛋白检测在急诊科中的临床应用前景  

The clinical prospect of detection serum S100B protein in emergency department

作　　者：孙宝迪[1] 邵旦兵[1] 聂时南[1] 

机构地区：[1]南京军区南京总医院急救医学科,江苏南京210002

出　　处：《中国急救医学》2015年第1期82-85,共4页Chinese Journal of Critical Care Medicine

基　　金：南京军区南京总医院青年基金课题（2014006）

摘　　要：S100B蛋白是一种小分子钙结合蛋白，主要表达于中枢神经系统的细胞，如星形胶质细胞、少突胶质细胞以及激活的施旺细胞等。血清中S100B蛋白浓度较低，但在某些病理状态下则可透过血脑屏障而急性升高，并且其升高的程度与病情、预后具有重要关系。目前研究认为，S100B蛋白与急诊科的多种疾病，如颅脑外伤、急性脑卒中、心脏骤停、失血性休克、中枢神经系统感染、阿尔茨海默病等疾病关系密切，本研究即是探讨检测S100B蛋白在急诊科的临床应用前景。S100B protein is a kind of calcium binding protein with small molecules, which mainly expressed by central nervous system cells, for example, astrocytes, oligodendrocytes and activated schwann cells, etc. The content of S100B protein in serum is low, however, it could elevate rapidly through the blood brain barrier in some pathological conditions. The content of S100B protein is related with patients＂ condition and prognosis. Current research suggested S100B protein had great relationship with traumatic brain injury, acute brain stroke, cardiac arrests, hemorrhagic shock, infection of central nervous system and Alzheimer disease, etc. The spectrum of diseases in emergency department is complicated. Diseases such as traumatic brain injury, acute brain stroke hemorrhagic shock, infection of central nervous system and cardiac arrests are common diseases in emergency department. Therefore, the authors consider that the detection of serum S100B protein in emergency department has great prospect of clinical application.

关 键 词：S100B蛋白 急诊 临床 检测 

分 类 号：R651.15[医药卫生—外科学]