双歧杆菌三联活菌联合不同剂型消旋卡多曲治疗婴幼儿病毒性肠炎的临床观察  

Clinical Observation of Bifid-triple Viable Combined with Different Dosage Forms of Racecadotril in the Treatment of Infant Viral Enteritis

作　　者：姚云 

机构地区：[1]余姚市第二人民医院儿科,浙江余姚315400

出　　处：《中国药房》2015年第3期331-333,共3页China Pharmacy

摘　　要：目的：观察双歧杆菌三联活菌联合不同剂型消旋卡多曲治疗婴幼儿病毒性肠炎的疗效和安全性。方法：128例病毒性肠炎患儿随机均分为观察组和对照组。两组患者均给予静脉补液,根据脱水程度及电解质测定情况调整补液张力、电解质和补液量以纠正水、电解质及酸碱平衡失调等常规治疗＋喜炎平注射液5~10 mg/（kg·d）加入5%葡萄糖注射液100 ml中静脉滴注,每日1次＋双歧杆菌三联活菌散剂1/2包,温水冲服,每日3次。在此基础上,对照组患儿给予消旋卡多曲颗粒1.5 mg/kg,口服,每日3次;观察组患儿给予消旋卡多曲口腔崩解片1.5 mg/kg,每日3次。两组患儿疗程均为7 d10观察两组患儿临床疗效、治疗顺应性、临床症状恢复时间及不良反应发生情况。结果：观察组患儿总有效率、总配合率均显著高于对照组,观察组患儿退热时间、止吐时间、止泻时间、脱水纠正时间均显著低于对照组,两组比较差异均有统计学意义（P〈0.05）。两组患儿不良反应发生率比较,差异无统计学意义（P〉0.05）。结论：双歧杆菌三联活菌联合消旋卡多曲口腔崩解片治疗婴幼儿病毒性肠炎较双歧杆菌三联活菌联合消旋卡多曲颗粒疗效更显著,安全性相似。OBJECTIVE： To observe therapeutic efficacy and safety of bifid-triple viable combined different dosage forms of racecadotril in the treatment of infant viral enteritis. METHODS： 128 cases of viral enteritis were randomly divided into observation group and control group. Both groups were given conventional fluid therapy, routine therapy （adjusting the amount and tension of rehydration, electrolyte according to dehydration properties＇ and electrolyte to correct water, electrolyte and acid-base disturbance）, Xiyanping injection 5-10 mg/（kg.d） added into 5% Glucose injection 100 ml intravenously once a day, and half a bag of Bifid-triple viable powder orally 3 times a day. Control group was additionally given Racecadotril granules 1.5 mg/kg orally 3 times a day; observation group was additionally given Racecadotril orally disintegrating tablets 1.5 mg/kg 3 times a day. Treatment course of 2 groups lasted for 7 days. Clinical efficacy, therapy compliance, recovery time of clinical symptom and the occurrence of ADR were observed in 2 groups. RESULTS： The total effective rate and overall rate of observation group were significantly higher than those of control group; the defervescence time, antiemetic time, antidiarrheal time and dehydration correction time of observation group were significantly shorter than those of control group; there was statistical significance（P〈0.05）. The incidence of ADR had no statistical significance between 2 groups （P〉0.05）. CONCLUSIONS： Bifid-triple viable combined with Racecadotril orally dis- integrating tablets is more effective than bifid-triple viable combined with Racecadotril granules in the treatment of infant viral enter- itis, and they have similar safety.

关 键 词：双歧杆菌三联活菌 消旋卡多曲口腔崩解片 消旋卡多曲颗粒 病毒性肠炎 

分 类 号：R453.9[医药卫生—治疗学]