CS/PMA30水凝胶的制备及其对中性红控释性能的研究  

Preparation and control release properties of chitosan electrostatic assembly with polyanion bearing phosphorylcholine groups

作　　者：宫铭[1] 宋成建[1] 曲建林[1] 汪广恒[1] 于伟[1] 宫永宽[2] 

机构地区：[1]西安科技大学化学与化工学院,西安710054 [2]西北大学化学与材料科学学院合成与天然功能分子化学教育部重点实验室,西安710069

出　　处：《功能材料》2015年第5期5075-5078,5083,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(20974087);陕西省自然基础研究计划资助项目(2014JQ2051)

摘　　要：将聚阳离子壳聚糖(CS)与聚阴离子甲基丙烯酰氧乙基磷酰胆碱-甲基丙烯酸二元共聚物(poly(MPC-co-MA),PMA30)进行静电复合,制备CS/PMA30聚离子水凝胶,并用红外(IR)、扫描电镜(SEM)分别对其特征官能团、表面形貌进行表征。然后,以中性红为模型药物对CS/PMA30水凝胶的控释性能进行研究。结果表明,CS/PMA30体系是通过静电作用形成的物理交联水凝胶,对模型药物中性红具有明显的控释性和pH值响应性。该水凝胶具有良好生物相容性有望在药物控释、组织工程等领域具有巨大的应用前景。该研究为进一步提高水凝胶的生物相容性提供了一个新的途径。Novel polyelectrolyte hydrogels were prepared by polycation chitosan(CS)and polyanionic poly(2-methacryloyloxyethyl phosphorylcholine-co-methacrylic acid)(poly(MPC-co-MA),PMA30).The PMA30(the actual percentages of MPC unit in PMA30 determined by 1 H-NMR was 28%)was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine(MPC)and methacrylic acid(MA).Fourier transform infrared spectra(FT-IR)and scanning electron microscopy(SEM)confirmed that the formation of the polyelectrolyte hydrogels was attributed to the strong electrostatic interaction between cationic groups in CS and anionic groups in PMA30.Potential applications of the hydrogels matrices in controlled drug delivery were also examined.In vitro release showed that neutral red release could be controlled by choosing the composition and pH.This facile method of fabricating CS/PMA30 hydrogels bearing phosphorylcholine groups may have potential applications in the fields of drug delivery,tissue engineering,and cell culture.

关 键 词：壳聚糖 水凝胶 磷酰胆碱 控释性能 

分 类 号：O631.13[理学—高分子化学]