佐匹克隆治疗老年失眠症患者的临床研究  

Clinical study of Zopiclone in treatment of elderly insomnia

作　　者：盛承东[1] 宋苏琪 李军[1] 

机构地区：[1]安徽医科大学附属巢湖医院精神科,安徽巢湖238000

出　　处：《中国民康医学》2015年第4期16-17,86,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨采用佐匹克隆治疗老年失眠症的临床效果及安全性。方法:选取90例老年失眠症患者,随机将其分成研究组和对照组各45例。对照组患者每晚睡前服用1mg艾司唑仑,而研究组患者则在每晚睡前服用7.5 mg佐匹克隆,共服用2周,利用睡眠障碍量表(SDRS)和药物不良反应量表(TESS)对两组患者的治疗效果及不良反应进行分析比较。结果:研究组患者治疗总有效率为95.6%,显著高于对照组77.8%的治疗总有效率,差异具有统计学意义(P<0.05);研究组患者治疗后SDRS评分较治疗前和对照组治疗后均明显缩短,数据差异具有统计学意义(P<0.05);研究组患者不良反应发生率明显低于对照组(P<0.01)。结论:在老年失眠症患者中采用佐匹克隆治疗方案具有更显著的疗效,安全性更高,不良反应少,值得临床推广及应用。Objective： To investigate clinical efficacy and safety of Zopiclone in treatment of insomnia in the elderly. Meth-ods： 90 cases of elderly patients with insomnia were randomly divided into study group and control group, 45 cases in each group. Thepatients of control group took 1mg Estazolam every night at bedtime for two weeks, while those in study group took 7. 5mg Zopiclone ev-ery night at bedtime for two weeks. The treatment effects and adverse reactions in both groups were analyzed and compared by usingsleep dysfunction rating scale （SDRS） and treatment emergent symptom scale （TESS）. Results： The total effective rate of study groupwas 95. 6%, and was significantly higher than 77. 8% of control group, and the difference was statistically significant （P〈0. 05）. TheSDRS scores of study group after the treatment were significantly lower than those before the treatment and control group after the treat-ment, and the differences were statistically significant （P〈0. 05）. The incidence rates of adverse reactions of study group were signifi-cantly lower than those of control group （P〈0. 01）. Conclusions： In elderly insomnia, Zopiclone has a more significant effect, moresafety, and less adverse reactions, and is worthy of promotion and application.

关 键 词：佐匹克隆 老年 失眠症 

分 类 号：R592[医药卫生—老年医学]