类风湿性关节炎患者铁调素的检测意义  

Significance of hepcidin in patients with rheumatoid arthritis

作　　者：曾婷[1] 宋超英[1] 施丹[1] 顾科峰[1] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院血液内科,202150

出　　处：《疑难病杂志》2015年第1期33-35,共3页Chinese Journal of Difficult and Complicated Cases

基　　金：上海市崇明县卫生局科研项目(No.CW2013-02)

摘　　要：目的检测类风湿性关节炎(RA)患者血清铁调素(Hepc)水平的变化,并探讨其临床意义。方法2012年8月—2014年2月接受治疗的RA患者72例作为病例组,选取正常体检人群54例作为健康对照组。以Hepc的血清水平(5.86 ng/ml)为界限将RA组分为正常亚组和升高亚组。比较2组受试者的炎性因子、血红蛋白(Hb)、Hepc水平和疾病活动性评分(DAS28),并探讨RA患者血清Hepc水平与患者临床指标间的相关性。结果 RA组患者的CRP、TNF-α、IL-6、Hb和Hepc的水平均显著高于健康对照组,差异具有统计学意义(t=6.445、3.293、3.910、2.874,8.572,P均<0.01);Hepc正常亚组患者的DAS28评分、IL-6水平均显著低于Hepc升高亚组(t=3.142、4.420,P均<0.01);RA组患者的Hepc水平与DAS28、类风湿因子(RF)、IL-6水平呈线性正相关关系(r=0.288,P<0.01;r=0.271,P=0.01;r=0.301,P=0.02)。结论 Hepc与RA患者的机体炎性状况、疾病活动程度有着明显的相关性。Objective To detect the changes of the levels of rheumatoid arthritis（RA） patients serum hepcidin（Hepc）,and to explore its clinical significance.Methods From 2012 August to 2014 February,72 patients with RA were selected as RA group,54 cases with normal physical examination were enrolled as healthy control group.With the serum level of Hepc（5.86 ng/ml） as the limit of RA,they were divided into normal subgroup＇s and the elevation subgroup.Inflammatory factor,hemoglobin（Hb）,lhe level of Hepc and disease activity score 28（DAS28） were compared between the 2 groups of subjects,and to explore the correlation between clinical indexes and serum Hepc level in patients with RA.Results RA group＇s CRP,TNF alpha,IL-6,Hb and Hepc levels were significantly higher than that in healthy control group with statistically significant difference（t =6.445,3.293,3.910,2.874,8.572.P〈0.01）;Hepc normal subgroup＇s DAS28 scores,IL-6levels were significantly lower than the Hepc elevation subgroup（t =3.142,4.420,P〈0.01）;Hepc levels of patients in the RA group were positive correlated with disease activity score（DAS28） and rheumatoid factor（RF）,IL-6 level（r =0.288,P〈0.01;r =0.271,P =0.01;r =0.301,P =0.02）.Conclusion The level of Hepc has closely relationship to inflammatory status and disease activity in RA patients.

关 键 词：关节炎 类风湿性 铁调素 血红蛋白 

分 类 号：R593.22[医药卫生—内科学]