聚乙二醇干扰素治疗不同中医证型的HBeAg阴性慢性乙型肝炎的疗效分析  

Analysis of Curative Effect of Pegylated-Interferon on Treatment of Different TCM Syndromes of Patients with HBeAg Negative Chronic Hepatitis B

作　　者：肖倩[1] 梁重峰[1] 谭善忠[1] 徐立华[1] 

机构地区：[1]南京市第二医院,江苏南京210003

出　　处：《中医药导报》2015年第3期11-13,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：南京市医学科技发展资金(青年卫生人才培养工程;QRX11096)

摘　　要：目的:观察聚乙二醇干扰素对两种不同中医证型的HBe Ag阴性慢性乙型肝炎患者的疗效。方法:选择HBeAg阴性的慢性乙肝患者56例,根据中医辨证分为肝郁脾虚型和湿热中阻型两组,使用聚乙二醇干扰素抗病毒治疗,疗程为48周,停药后随访24周。比较两组患者的ALT复常率、HBV-DNA阴转率及HBsAg定量的下降情况。结果:治疗第12、24周,两组ALT复常率比较,差异无统计学意义(P>0.05),但湿热中阻型有较好的趋势;治疗48周及停药随访第24周,两组ALT复常率比较,差异有统计学意义(P<0.05);两组HBV-DNA阴转率比较,差异无统计学意义(P>0.05);HBsAg定量下降情况肝郁脾虚型优于湿热中阻型,差异有统计学意义(P<0.05)。结论:聚乙二醇干扰素治疗肝郁脾虚型乙肝患者疗效优于湿热中阻型。Objective： To observe the efficacy of Pegylated-interferonin HBeAg negative chronic hepatitis B patients on two kinds of different TCM syndrome types. The 56 cases of patients with HBeAg negative chronic hepatitis B, according to syn- drome differentiation of traditional Chinese medicine were derided into two groups, with liver stagnation and spleen deficiency pattern and thedamp-heat pattern; Pegylated-interferon was used as antiviral therapy for 48 weeks, followed up for 24 weeks af- ter drug withdrawal. The recovery rate of ALT, HBV-DNA negative conversion rate and the decline of HBsAg quantitative were compared between different TCM syndromes. Results： In the treatment of the first 12, 24th weeks, there was no significant dif- ference on ALT recovery rate between the two groups（P〉O.05）, but the damp-heat pattern was in a good trend; in the 48th weeks of treatment and follow-up of 24th weeks,there was significant difference on the recovery rate of ALT （P〈0.05）; there was no significant difference on the HBV-DNA negative conversion rate （P〉0.05）; the liver stagnation and spleen deficiency pattern showed better effect on HBsAg quantitative reduction, with significant difference （P〈0.05）. Conclusion： Pegylated-interferon can provide better efficacy for the liver stagnation arid spleen deficiency pattern than the damp-heat pattern in patients with hepatitis B.

关 键 词：慢性乙型肝炎 肝炎E抗原 干扰素α~2a 辨证分型 

分 类 号：R256.4[医药卫生—中医内科学]