基于聚类分析的支气管哮喘急性发作用药规律探讨  

Analysis of Regularity in Treating Acute Exacerbation of Asthma Based on Cluster Analysis

作　　者：吴建军[1] 李欣[2] 靳锐锋[1] 秦阳[1] 崔红生[1] 

机构地区：[1]北京中医药大学第三附属医院,北京100029 [2]中国中医科学院眼科医院,北京100040

出　　处：《中国中医急症》2015年第1期10-12,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30672567)

摘　　要：目的探讨中医药治疗支气管哮喘急性发作的常用药物和配伍规律。方法以1991年1月至2013年12月在省级以上期刊发表,以中药汤剂联合西医抗炎、止咳化痰平喘治疗支气管哮喘急性发作,且经过临床疗效观察有效的中药复方为研究对象,对其用药进行聚类分析,探索中医药治疗支气管哮喘急性发作的常用药物和配伍规律。结果支气管哮喘急性发作使用最多的药物为炙麻黄、甘草、苦杏仁、半夏、苏子、地龙、五味子。聚类分析显示支气管哮喘急性发作常用药物可分为6类,包括解表清里、温肺化饮、化痰、祛风止咳、补益肺脾、活血化瘀等药物。结论支气管哮喘急性发作的病因病机分邪实、正虚两端,邪实以痰热、寒饮为主,正虚以肺脾气虚为主,用药以解表清里、温肺化饮、补益肺脾类中药为主。Objective： To discuss on the commonly used drugs and law of compatibility of TCM in treatment of acute exacerbation of asthma. Methods： TCM compound was taken to study,which was effective in clinical combined with Western Medicine,such as anti-infection、expectorant,cough mixture in the treatment of acute exacerbation of Asthma,published in 1991 January to 2103 December on the journal. Cluster analysis was performed on the drug to explore the commonly used drugs and law of compatibility of TCM in treatment of acute exacerbation of asthma. Results： The most used drug in TCM on treatment of acute exacerbation of Asthma were honey-fried herba ephedrae,Licorice,almond,Pinellia,Perilla,Earthworm,Schisandra chinensis. Clustering analysis showed that the drugs could be divided into six categories,including relieving superficies and clearing interior,warming lung to reduce watery phlegm,relieving cough and asthma,invigorating lung and spleen,promoting blood circulation for removing blood stasis,et al. Conclusion： The etiology and pathogenesis of acute exacerbation of Asthma divide into excess of pathogen and deficiency of vital qi. Excess of pathogen was main in phlegm heat,cold drink.Deficiency of vital qi was main in qi deficiency of lung and spleen.The main drug which were used in the treatment of acute exacerbation of asthma were relieving superficies and clearing interior,warming lung to reduce watery phlegm,invigorating lung and spleen.

关 键 词：支气管哮喘急性发作 用药规律 聚类分析 中医药 

分 类 号：R562.25[医药卫生—呼吸系统]