结肠透析并纤支镜灌洗对肺炎合并脓毒症患者血清C反应蛋白水平的影响  

Effect of Colon Dialysis and Fiberoptic Bronchoscopy Alveolar Lavage on the CRP Level of Patients with Pneumonia Complicated Sepsis

作　　者：陈立[1] 韩悦[1] 吕波[1] 李兰[1] 

机构地区：[1]贵阳中医学院第一附属医院,贵州贵阳550001

出　　处：《中国中医急症》2015年第1期42-43,65,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：贵州省卫生厅科学技术基金项目(gzwkj2012-1-030);贵州省科技计划项目(黔科合中药字[2012]LKZ7057号)

摘　　要：目的观察通腑理肺汤结肠透析联合纤维支气管镜肺泡灌洗对肺炎合并脓毒症患者CRP水平的影响。方法将90例肺炎合并脓毒症患者随机分为3组,治疗组A、治疗组B、对照组各30例。治疗组A在常规治疗的基础上给予通腑理肺汤结肠透析联合纤维支气管镜肺泡灌洗;治疗组B在常规治疗基础上每日给予等量温水结肠透析联合纤维支气管镜肺泡灌洗;对照组在常规治疗基础上每日给予等量温水结肠透析。3组均于治疗前后记录患者体温、呼吸情况及血白细胞计数水平测定,并于治疗前、治疗1周末、治疗2周末测定血清C反应蛋白(CRP)水平。3组疗程均为2周。结果治疗后治疗组A体温、呼吸机白细胞计数水平均明显降低,显著低于治疗组B及对照组(P<0.05);与对照组相比,治疗组CRP水平明显降低,且治疗组A更为明显(P<0.05)。结论通腑理肺汤结肠透析联合纤维支气管镜肺泡灌洗能明显降低脓毒症患者体温、呼吸频率及白细胞计数水平,这可能与其降低血清C反应蛋白水平,减轻炎症反应有关。Objective： To explore the effect of colon dialysis and fiberoptic bronchoscopy alveolar lavage on the CRP level of patients with pneumonia complicated sepsis. Methods： 90 patients of pneumonia with sepsis were randomly divided into three groups,Tongfulifei Decoction colon dialysis combined fiberoptic bronchoscopy alveolar lavage treatment group [treatment group（A）],warm water colon dialysis combined fiberoptic bronchoscopy alveolar lavage treatment group[treatment group（B）],warm water colon dialysis group（control group） with 30 cases in each group. Before and after treatment,the body temperature,breathing and blood leukocyte count level were detected. The serum C-reactive protein（CRP） level was detected at the time point of before treatment,the first weekend and the second weekend of treatment. Course of treatment of all groups lasted for 2 weeks. Results： After treatment,body temperature and breathing machine white blood cell count of the treatment group A significantly decreased,significantly lower than those of the treatment group B and control group（P〈0.05）. The CRP level of treatment groups was significantly lower than that of control group,and the level of treatment group A was more obvious（P〈0.05）. Conclusion： Tongfulifei Decoction colon dialysis combined fiberoptic bronchoscopy alveolar lavage can significantly reduce body temperature,breathing rate and level of white blood cell count,which may relate to reducing serum CRP level and inflammation reactions.

关 键 词：通腑理肺汤 结肠透析 纤维支气管镜肺泡灌洗 C反应蛋白 

分 类 号：R563.1[医药卫生—呼吸系统]