心元胶囊治疗冠心病心绞痛有效性及安全性的Meta分析  

A Meta analysis of Xinyuan Capsule in Treating Patients with Unstable Angina

作　　者：高长春[1] 林淑梅[1] 徐国良[1] 秦玲[1] 

机构地区：[1]吉林大学第一医院二部,吉林长春130031

出　　处：《中国中医急症》2015年第1期52-55,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：吉林省科技厅科研项目(200905138)

摘　　要：目的用Meta分析的方法来研究心元胶囊治疗冠心病心绞痛的疗效及临床上应用是否安全。方法通过应用计算机对Cochrane图书馆临床对照试验资料库(2014年第2期)、中国(CNKI)学术文献总库(1979年至2014年6月)、万方数字化期刊库(1981年至2014年6月)、中文科技期刊数据库(1989年至2014年6月),Pubmed(1966年至2014年6月)、Embase(1966年至2014年6月)进行检索,对临床随机对照试验按照一定的入选标准和排除标准进行选择、对文献的质量进行评价,从中找到所需要的数据,应用软件Rev Man5.3对提取的数据来进行Meta分析。结果经过初步检索,有269篇文献入选,按照入选标准和排除标准最终6篇关于心元胶囊治疗冠心病心绞痛的随机对照研究入选。应用心绞痛缓解作为标准:χ2=5.28,df=5,P=0.38,合并OR=4.94,95%CI[2.94,8.28],Z=6.05(P<0.00001);应用心电图改善作为标准:χ2=5.84,df=5,P=0.32,合并OR=2.70,95%CI[1.89,3.86],Z=5.44(P<0.00001);各试验组均未发现严重的不良反应。结论心元胶囊治疗冠心病心绞痛缓解心绞病症状及改善心电图都是有效的,且临床应用安全。Objective： To approach the efficacy and safety of Xinyuan Capsule in treating patients with unstable angina（UA）. Methods： We searched the Cochrane Central Register of Controlled Trials（Issue2,2014）,MEDLINE（1991 to June 2014）,EMbase（1991 to June 2014）,CBMdisc（1991 to June 2014） and CNKI（1994 to June2014）. We also hand searched relevant journals and conference proceedings.Randomized controlled trials（RCTs）in which Xinyuan Capsule was used to treat patients with UA were collected. Then we screened the retrieved studies according to predefined inclusion and exclusion criteria,evaluated the quality of included studies,and performed meta analyses by using Rev Man 5.3 software. Therapeutic effects of angina pectoris and efficacy of electrocardiogram（ECG） were selected as the study indices. Results： A total of 266 articles were found and 6 of which were finally included. Therapeutic effects of angina pectoris were selected as the study indices,χ^2=5.28,df=5,P = 0.38.OR=4.94,95% CI [2.94,8.28],Z=6.05（P〈0.00001）. ECG were selected as the study indices,χ^2=5.84,df=5,P = 0.32.OR=2.70,95% CI [1.89,3.86]. Z=5.44（P〈0.00001）. Conclusion： Xinyuan Capsule is effective and safe to treat patients with unstable angina.

关 键 词：心元胶囊 冠心病 心绞痛 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]