匝迪-5味丸对急性应激所致行为绝望小鼠的抗抑郁作用研究  

Antidepressant Effect of Zadi-5 Pill on Mouse Models with Depressant

作　　者：呼日乐巴根[1,2] 佟海英[1] 莲花[2] 乌兰其其格[2] 白龙[2] 阿古拉[2] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]内蒙古医科大学,内蒙古呼和浩特010110

出　　处：《中国中医急症》2015年第1期56-58,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：内蒙古医科大学"英才培育"项目(2014YCPY003)

摘　　要：目的初步观察匝迪-5味丸的抗抑郁作用。方法通过小鼠悬尾实验(TST)、小鼠强迫游泳实验(FST)及利血平致小鼠抑郁模型,并以盐酸氟西汀为对照,观察连续7 d给匝迪-5味丸后对急性应激所致行为绝望小鼠的影响及腹腔注射利血平诱发抑郁模型小鼠的眼睑下垂、运动不能及体温变化的影响。结果与空白组比较,阳性对照组、匝迪-5味丸高、中剂量组均能缩短小鼠TST不动时间(P<0.01);与空白组比较,阳性对照组,匝迪-5味丸高、中、低剂量组均能缩短小鼠FST不动时间(P<0.05或P<0.01)。与模型组比较,阳性对照组,匝迪-5味丸的高、中、低剂量组明显对抗利血平所致小鼠眼睑下垂、运动不能及体温降低(P<0.05或P<0.01)。结论匝迪-5味丸能改善急性应激所致行为绝望小鼠及利血平诱导小鼠抑郁状态,其作用机制值得进一步研究。Objective： To discuss the antidepression effect of Zadi-5 Pill. Methods： Depressant model was establised by the conduct forced swimming test,tail suspension test on mice and reserpine test to make depression model.The effect of Zadi-5 Pill on acute stress caused despair behavior of mice after 7d and recorded rectal temperature change and blepharoptosis and akinesia after ip resperine. Meanwhile,these indicators were compared to Fluoxetine Hydrochloride group. Results： Compared with blank group,positive control group and Zadi-5 Pill high,middle,low dose groups significantly shortened the immobility time in forced swimming test（P〈0.05） and tail suspension test（P〈0.01）. Compared with the model group,positive control group and Zadi-5 Pill high,middle,low dose groups can reverse the blepharoptosis,the akinesia and abnormally low body temperatures induced by reserpine（P〈0.05 or P〈0.01）. Conclusion： Zadi-5 Pill can significantly reduce acute stress caused despair behavior and reverse depressive state induced by reserpine,and then have anti-depression affect. The pharmacologic mechanism of Zadi-5 Pill may concerned with preventing monoamine metabolites to increase monoamine content.

关 键 词：匝迪-5 抗抑郁作用 急性应激 行为绝望 

分 类 号：R285.5[医药卫生—中药学]