混其勒-7抗炎镇痛作用及其机制初探  

Hunqilu-7 Inflammatory and Analgesic Effect and Mechanism of Exploration

作　　者：陈晓北[1] 叶冬梅[1] 

机构地区：[1]赤峰学院医学院,内蒙古赤峰024000

出　　处：《中国医药指南》2015年第1期22-23,共2页Guide of China Medicine

摘　　要：目的研究蒙药混其勒-7对小鼠的抗炎镇痛作用,初步探讨其作用机制。方法采用耳廓炎症肿胀实验测定其抗炎作用,热板痛阈和醋酸扭体实验测定其镇痛作用,ELISA法测定小鼠血清中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)的表达情况。结果中剂量混其勒-7可提高小鼠痛阈,减少扭体次数,并且改善二甲苯引发的炎症表现,其抗炎作用可能与TNF-α有关,而镇痛作用与TNF-α无关。结论混其勒-7具有抗炎镇痛作用,其抗炎作用可能与TNF-α有关。Objective To study the Mongolian Hunqile-7 anti-inflammatory and analgesic effect in mice, a preliminary explore its action mechanism. Methods Using auricle inflammation swelling experiments show its anti-inflammatory action, hot plate pain threshold and acetic acid twisting experiment measure its analgesic action, ELISA method for determination of mice serum tumor necrosis factor alpha（tumor necrosis factor-α, TNF-α）expression. Results Dose mixed in the Hunqile-7 can increase the pain threshold of mice, decrease the times of twisting the body and improve inflammation caused by xylene, its anti-inflammatory effects may be associated with the TNF-a, and analgesic action has nothing to do with the TNF-α.Conclusion Mix the anti-inflammatory and analgesic effects of Hunqile-7, its anti-inflammatory effects may be associated with the TNF-α.

关 键 词：混其勒-7 抗炎镇痛 TNF-Α 

分 类 号：R971.1[医药卫生—药品]