慢性肾脏病对认知功能障碍影响的Meta分析  

Influence of Chronic kidney disease on cognitive impairment: A Meta-analysis

作　　者：李静[1] 李月春[1] 王宝军[1] 侯国存[2] 

机构地区：[1]包头市中心医院神经内科,内蒙古包头014040 [2]包头市中心医院肾脏内科

出　　处：《疾病监测与控制》2014年第12期753-756,共4页Journal of Diseases Monitor and Control

摘　　要：目的系统评价慢性肾脏病(CKD)与认知功能障碍发生风险的相关性。方法检索了Pubmed/MEDLINE、EMBASE和Cochrane Library(2013年10期)电子数据库,查找慢性肾脏病和认知功能障碍相关的横断面研究,采用Rev Man5.2软件进行Meta分析。结果 Meta分析结果显示:(1)社区老年人为研究对象的4个横断面研究中,CKD组老年人发生认知障碍风险明显增加[OR=1.32,95%CI(1.01,1.72),P=0.04;OR=1.53,95%CI(1.1,2.12),P=0.01];(2)慢性肾脏病患者为研究对象的2个横断面研究中,随e GFR下降,发生认知障碍风险越高[OR=1.58,95%CI(1.17,2.12),P=0.003]。结论 CKD增加认知功能障碍的风险,且肾功能越差发生认知障碍风险越高,CKD是认知障碍发生的独立危险因素。Objective To systematically review the impact of CKD on cognitive impairment. Methods We electronically searched Pubmed/Medline, EMBASE and The Cochrane Library （Issue 10, 2013） for collecting relevant Cross-sectional studies about the association of CKD and cognitive decline from inception to October, 2013. Meta-analysis was conducted using RevManS.2 software. Results The results of meta-analysis showed that in community-dwelling elderly individuals an association of cognitive impairment in CKD patients compared with patients without CKD [OR=1.32,95%CI （1.01, 1.72）, P=-0.04; OR=1.53, 95%CI （1.1, 2.12）, P=-0.01]. Meanwhile, in CKD patients as eGFR decreases, the incidence risk of cognitive impairment is higher [OR=1.58, 95%CI （1.17, 2.12）, P=0.003]. Conclusions Our results suggest CKD being a significant and independent somatic risk factor in the development of cognitive decline.

关 键 词：慢性肾脏病 认知功能障碍 横断面研究 META分析 

分 类 号：R692[医药卫生—泌尿科学]