远志总皂苷对湿阻中焦大鼠胃及脂质代谢的影响  

Effects of polygala total saponins on stomach and lipid metabolism of rats with damp blockage of middle energizer

作　　者：文莉 孙磊 唐佩佩 李颖修 张智华 

机构地区：[1]湖北省中药资源与中药化学省级重点实验室,湖北武汉4300061

出　　处：《中国医院药学杂志》2015年第2期99-104,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然基金项目(编号:81102888)

摘　　要：目的:研究不同剂量远志总皂苷对湿阻中焦大鼠的胃的双向作用以及对脂质代谢的影响。方法:选用湿阻中焦证大鼠模型,采用不同剂量的远志总皂苷予以治疗。给药后,采用病理组织学切片观察胃损伤,测定血清胃泌素及血脂三酰甘油(TG)水平。结果:模型大鼠胃粘膜有少量溃疡点,固有层聚集大量炎性细胞,血清胃泌素水平上升,肝脏呈脂肪肝样变,血脂升高。远志总皂苷400 mg·kg-1剂量组大鼠出现胃粘膜充血肿胀,胃粘膜上皮细胞融解,胃泌素水平及血脂没有改变;200,100 mg·kg-1剂量组大鼠胃粘膜炎性细胞,较模型组大鼠胃粘膜明显减少,血清胃泌素和血脂明显下降,比较模型组,P<0.05。各组大鼠肝脏颜色均正常。结论:给予100 mg·kg-1的远志总皂苷有显著的保护胃粘膜及降脂作用,而给予400 mg·kg-1远志总皂苷则具有显著胃刺激性。OBJECTIVE To investigate the mutual effects of total saponins of Radix polygalae at different doses and stomachs of rats with damp blockage of middle energizer and lipid metabolism.METHODS Rat model of damp blockage of middle energizer was adopted,different doses of the total saponins from Radix polygalae were administrated to the rats.After drug administration,gastric injuries were observed through histopathological sections,levels of serum gastrin and blood lipid TG were determined.RESULTS In model rats,there were a few ulcer points on gastric mucosa and a large number of inflammatory cells in the basal layer of the rat stomach,level of serum gastrin increased,liver showed changes of fatty liver,level of blood lipid was raised.In the group administering 400 mg·kg-1 of total saponins from Radix Polygalae,rats had hyperemia and swollen and congested gastric mucosa,dissolved gastric mucosal epitheliaa,but unchanged levels of gastrin and blood lipid.In the group administering 200 mg/kg and 100 mg/kg of total saponins from Radix Polygalae,compared to rats in model group,gastric mucosal inflammatory cells and levels of serum gastrin and blood lipid all decreased evidently（P〈0.05）.Liver color of all rats was normal.CONCLUSION Administration of 100 mg·kg-1 total saponins from Radix polygalae can obviously protect gastric mucosa and decrease level of blood lipid,while administration of 400 mg/kg total saponins from Radix polygalae can irritate the stomach significantly.

关 键 词：远志总皂苷 湿阻中焦 胃泌素 三酰甘油 胃粘膜 病理组织学 

分 类 号：R96[医药卫生—药理学]