基于近红外漫反射光谱的盐酸左西替利嗪片判别分析  

Discriminant analysis for levocetirizine hydrochloride tablets based on near-infrared diffusion spectroscopy

作　　者：陈芬芬[1] 高闽光[1] 徐亮[1] 

机构地区：[1]中国科学院安徽光学精密机械研究所、中国科学院环境光学与技术重点实验室,安徽合肥230031

出　　处：《量子电子学报》2015年第1期1-7,共7页Chinese Journal of Quantum Electronics

基　　金：中国科学院战略性先导科技专项(XDB05050300)资助

摘　　要：当前市场上的药品种类繁多,因此对不同厂商的同类药品进行识别分析对规范医药市场及保障人民用药安全有重要现实意义.实验采用基于傅里叶变换近红外漫反射光谱的光谱判别分析方法,结合矢量归一化方法和导数方法对光谱进行预处理,对不同品牌的盐酸左西替利嗪片建立定性识别模型,并用验证集样品对模型进行验证。验证结果表明,通过光谱库判别分析法建立识别模型不能正确识别同一厂家的两种样品,但对不同厂家盐酸左西替利嗪片的识别正确率为100%,该方法可以用于不同企业同类药品的快速定性识别和质量控制.As there are many different kinds of medicine on the market, it＇s significant to regulate medical market and ensure people＇s medication safety by identification analysis of different brands of drug. Spectral library discriminant analysis was applied to establish the qualitative identification model for different brands of levocetirizine hydrochloride tablets based on near-infrared diffusion spectroscopy. The spectral pretreat- ment method used consisted of vector normalization method and derivative method. Then the validation set was used to test the model. The results showed that the model can＇t correctly identify two samples of the same manufacturer, but samples from different manufacturers were classified correctly by the discriminant model, and the accuracy was 100%. This method can be used for rapid identification of similar medicines from different manufactures.

关 键 词：傅里叶光学 近红外光谱 盐酸左西替利嗪片 判别分析 快速鉴别 

分 类 号：O43[机械工程—光学工程] R917[理学—光学]