硝苯地平控释片联合氯沙坦治疗原发性高血压的临床研究  

Clinical Study on Nifedipine Release Tablets Combined with Losartan in the Treatment of Essential Hypertension

作　　者：王靖 

机构地区：[1]上海市崇明县新村乡社区卫生服务中心,上海202172

出　　处：《黑龙江医学》2015年第1期29-30,共2页Heilongjiang Medical Journal

摘　　要：目的：探讨硝苯地平控释片联合氯沙坦治疗原发性高血压的临床疗效。方法选取我院2010－01～2014－05间入院治疗的60例原发性高血压患者，采用抽签的方法分为联合组、硝苯地平组、氯沙坦组，每组各20例。联合组使用硝苯地平控释片联合氯沙坦进行联合治疗，硝苯地平组使用硝苯地平治疗，氯沙坦组使用氯沙坦进行治疗。三组患者的治疗周期均为8周，三组患者均每天测量血压，如果治疗效果欠佳，可以增加药量。结果三组患者在治疗了8周以后发现联合组的总有效率达到95％；硝苯地平组的总有效率达到50％；氯沙坦组的总有效率达到60％。三组血压均有下降，其中联合组的血压下降较为明显。结论硝苯地平控释片联合氯沙坦治疗原发性高血压的临床疗效要优于单独使用硝苯地平控释片和单独使用氯沙坦治疗原发性高血压。Objective To investigate the clinical effect of nifedipine release tablets combined with losartan in the treatment of essential hypertension.Methods Selecting 60 patients with essential hypertension in the hospital from Jan , 2010 to May, 2014.60 cases with lots of ways are divided into three groups combined group nifedipine group and losartan group , with 20 cases in each group.The combined group using nifedipine combined with losartan in combination therapy with nifedipine , nifedipine group , losartan group were treated with losartan.The treatment period of three groups was 8 weeks, and patients in 3 groups had blood pressure test every day.If the treatment effect was poor, the dosage could be increased.Results It is found that the total effective rate of patients in the combined group reached 95%;the total effective rate in the nifedipine group reached 50%; the total effective rate in the losartan group reached 60%.Blood pressure de-creased in the three groups , and the combined group blood pressure decreased most obviously.Conclusion The clinical curative effect of nifedipine release tablets combined with losartan in the treatment of essential hypertension is better than the single use of nifedipine GITS and separate use of losartan in the treatment of essential hypertension.

关 键 词：硝苯地平控释片 氯沙坦 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]