经鼻给药增加药物脑靶向的制剂方法  

Pharmaceutical methods to increase brain-targeted efficiency for nasal delivery drugs

作　　者：吴慧[1] 吴闻哲[1] 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《世界临床药物》2015年第1期50-55,共6页World Clinical Drug

摘　　要：药物进入脑部达到脑部病灶会受到血脑屏障的限制。鼻腔给药作为一种比较理想的脑部递药方式越来越受到重视。本文回顾近5年国内外研究进展,综述鼻腔给药增加药物脑靶向的促渗剂、黏膜黏附剂和新型给药系统的研究。The blood brain barrier（BBB） can block the drugs distribution to central nervous system（CNS）, which reduces the treatment efficacy of many brain diseases. Nasal drug delivery as an ideal drug delivery style to the brain is getting more and more attention. This paper describes the progress on how to increase brain-targeted efficiency of nasal delivery drugs by permeation enhancers, mucoadhesive agents and some new dosage formulations.

关 键 词：鼻腔给药 脑靶向 促渗剂 黏膜吸附剂 剂型 

分 类 号：R94[医药卫生—药剂学]