围绝经期妇女5项指标水平的变化及相关分析  

Changes and relationships of five indicators in perimenopausal women

作　　者：杨士军[1] 陆卫平[2] 谭维琴[1] 张金华[1] 

机构地区：[1]南京医科大学附属淮安第一医院核医学科,江苏淮安223300 [2]南京医科大学附属淮安第一医院内分泌科,江苏淮安223300

出　　处：《国际检验医学杂志》2015年第2期213-214,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨围绝经妇女血清雌二醇（E2）与β胶原降解产物（β-Crosslap）、Ⅰ型前胶原氨基端肽（PINP）、N端骨钙素（N-MlD）、甲状旁腺素（PTH）等水平的变化及关系。方法 2009年3月至2012年6月江苏淮安市第一人民医院体检妇女240例,按年龄分为20~〈40岁、40~〈45岁、45~〈50岁、50~〈55岁、55~〈60岁组。采用电化学发光法检测血清E2、β-Crosslap、PINP、N-MID、PTH等5项指标,比较5个年龄组5项指标的差异,并分析E2与其他4项指标,5项指标与年龄之间的相关性。结果围绝经期（40~〈60岁）妇女4个年龄组E2的水平均明显低于20~〈40岁组,比较差异均有统计学意义（P〈0.05）。围绝经期（40~〈60岁）妇女4个年龄组β-Crosslap、PINP、N-MID、PTH等4项指标水平均高于20~〈40岁组。围绝经期妇女E2水平与β-Crosslap、PINP、N-MID、PTH等4项指标均呈显著负相关（r分别为-0.61、-0.52、-0.47、-0.63,P〈0.05）。E2与年龄呈显著负相关（r=-0.72,P〈0.05）;β-Crosslap、PINP、N-MID、PTH等4项指标与年龄呈显著正相关（r分别为0.61、0.59、0.63、0.58,P〈0.05）。结论围绝经期妇女的血清E2、β-Crosslap、PINP、N-MID、PTH水平检测对围绝经期妇女的保健、骨代谢的研究具有重要价值。Objective To explore the changes and relationships of five indicators that estradiol and β-collagen degradation prod- ucts（β-Crosslap） ,proeollagen Ⅰ N-terminal peptide（PINP）,N terminal osteocalcin（N-MID）,parathyroid hormone（PTH） in perimenopausal women. Methods A total of 240 women were selected in this study and divided into five groups that 20-40 years old, 40-〈45 years old,45-〈50 years old,50-〈55 years old,55-〈60 years old group. The Electrochemical Luminescence method was used to detect the serum E2, β-crosslap, PINP, N-MID and PTH in 240 women. The differences on the five indicators were compared among the five years age groups. The correlation between E2 and other four indicators, between the five indicators and the age were be analyzed. Results E2 level of perimenopausal women （40-〈60 years old） was significant lower than that of the women who was 40-〈60 years old（P〈 0.05）, but the levels of β-Crosslap, PINP, N-MID and PTH of perimenopausal women were higher than those of the women who were 20-〈40 years old（P〈0.05）. There were negative correlations between E2 level and β-Crosslap,PINP,N-MID and PTH（r=-0.61 ,-0.52,-0.47,-0.63,P〈0.05）. There was a negative correlation between E2 level and age （r=- 0. 72,P〈0. 05）. The β-Crosslap, PINP, N-MID and PTH levels were positively correlated with age（r= 0. 61,0.59,0.63,0.58,P〈0.05）. Conclusion It is important value for perimenopausal women＇s health, bone metabolism research to detect the levels of serum E2,β-Crosslap,PINP, N-MID,PTH in perimenopausal women.

关 键 词：雌性激素 β胶原降解产物 Ⅰ型前胶原氨基端肽 N端骨钙素 甲状旁腺素 围绝经期妇女 

分 类 号：R580[医药卫生—内分泌]