超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系  

Relationship between high-sensitivity C-reactive protein, complement 3 and disease activity in systemic lupus erythematosus

作　　者：李晓洁[1] 周蕾[1] 陈宪[1] 王颖嫒[1] 

机构地区：[1]天津医科大学总医院风湿免疫科,天津300052

出　　处：《天津医科大学学报》2015年第1期63-64,71,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨超敏C反应蛋白(hs CRP)和补体C3与系统性红斑狼疮(SLE)疾病活动度间的关系。方法:选取SLE患者101例,根据SLE疾病活动性指数(SLEDAI)评分分为缓解组(n=73)和活动组(n=28),应用免疫透射比浊法检测101例患者血浆hs CRP,应用速率放射比浊法检测患者血清C3,分组比较上述指标及其与疾病活动度的相关性。采用独立样本t检验、χ2检验和Pearson相关分析进行统计学分析。结果:活动组SLE患者hs CRP水平高于缓解组[(9.03±6.84)mg/L]vs[(1.51±1.27)mg/L],活动组SLE患者补体C3水平低于缓解组[(677.00±389.75)mg/L]vs[(877.94±316.54)mg/L],分别比较差异有统计学意义(P<0.05);hs CRP水平与SLEDAI评分呈正相关(r=0.649,P<0.01),补体C3水平与SLEDAI评分呈负相关(r=-0.590,P<0.01)。结论:Hs CRP和补体C3水平与SLE疾病活动密切相关,可作为SLE患者疾病活动度监测和治疗效果的评估指标。Objective： To explore the relationship between the levels of high-sensitivity C-reactive protein （hsCRP）, complement 3（C3） and disease activity in patients with systemic lupus erythematosus （SLE）. Methods： A total of 101 patients with SLE were divided into two groups in accordance with SLEDAI scores, the active group （n=28）and the remission group （n=73）.Plasma was assayed for hsCRP by immunological transmission turbidimetry,and serum was assayed for C3 by radiation rate nephelometry. All data were analyzed by Students＇t test, Chi-squared test and Pearson regression analysis. Results： Patients in active group had higher hsCRP levels than patients in remisson group [（9.03±6.84）mg/L] vs [（1.51±1.27 ）mg/L], and patients in active group had lower C3 levels than patients in remisson group [（677.00±389.75）mg/L] vs [（877.94±316.54）mg/L], differences were statistically significant（P〈0.05）;hsCRP levels were positively correlated with SLEDAI score（r=0.649, P〈0.01）, C3 levels and SLEDAI score were negatively correlated（r=-0.590,P〈0.01）. Conclusion： HsCRP and C3 are closely related with SLE activity and can be used as one of the indicators for SLE activity and the clinical result.

关 键 词：红斑狼疮 系统性 超敏C反应蛋白 补体C3 疾病活动度 

分 类 号：R593.241[医药卫生—内科学]