老年慢性阻塞性肺疾病急性加重期患者血浆中纤维蛋白原监测的临床意义  

The clinical significance of plasma fibrinogen monitoring in elderly patients with chronic obstructive pulmonary disease in acute exacerbation period

作　　者：王垚[1] 周薇[1] 

机构地区：[1]北京老年医院呼吸科,100095

出　　处：《中国医药》2015年第2期169-171,共3页China Medicine

摘　　要：目的讨论老年慢性阻塞性肺疾病急性加重期（AECOPD）患者纤维蛋白原（Fib）监测的临床意义。方法完全随机选择AECOPD患者45例作为观察组，非COPD相对健康者55例作为对照组。观察组入院24 h内、对照组就诊时分别检测血凝四项[凝血酶原时间（PT）、部分活化凝血活酶时间（APTT）、凝血酶时间（TT）、Fib]、D二聚体、C反应蛋白。以上指标2组间做比较。结果观察组患者TT较对照组长，差异有统计学意义［（12.0±2.3）s比（11.1±1.1）s］（P〈0.05）；Fib、C反应蛋白水平较对照组高，差异有统计学意义［（3.9±1.1）g/L比（3.4±0.7）g/L、（33.3±26.6）mg/L比（4.4±2.2） mg/L］（P〈0.01）；PT、APTT、D二聚体水平2组间差异无统计学意义（P〉0.05）。结论老年AECOPD患者Fib水平明显增高，提示血液呈高凝状态。Fib可作为AECOPD炎症反应及病情监测的指标之一。Objective To explore the clinical significance of plasma fibrinogen（Fib） monitoring in elderly patients with chronic obstructive pulmonary disease during acute exacerbation period（AECOPD）.Methods Totally 45 AECOPD people（the observation group） and 55 COPD people（the control group） were completely random selected. The general data, 4 coagulation parameters [prothrombin time（PT）, activated partial thromboplastin time（APTT）, thrombin time（TT）, Fib] within 24 hours of admission, Ddimer and Creactive protein （CRP） were collected and compared between 2 groups. ResultsIn the observation group, TT was longer than that in the control group; the difference was statistical significance[（12.0±2.3）s vs （11.1±1.1）s]（P〈0.05）. Fib and CRP levels were higher than those in the control group; the difference was statistical significant[（3.9±1.1）g/L vs （3.4±0.7）g/L,（33.3±26.6）mg/L vs （4.4±2.2） mg/L]（P〈0.01）; there was no difference between the two groups regarding PT,APTT and Ddimer（P〉0.05）.ConclusionsElderly patients with AECOPD fibrinogen levels are significantly increased, which suggests that hypercoagulable states; Fib can be used as an indicator of AECOPD inflammation and disease monitoring.

关 键 词：慢性阻塞性肺疾病 急性加重期 纤维蛋白原 D-二聚体 凝血功能 

分 类 号：R563[医药卫生—呼吸系统]