地佐辛对苏芬太尼诱发的全身麻醉诱导期呛咳反应的预防作用  

Impact of dezocine on prevention of sufentanil-induced cough during anesthesia induction

作　　者：曾庆玲[1] 唐培佳[1] 徐月秀[1] 梁勇升[1] 

机构地区：[1]广西壮族自治区玉林市第一人民医院麻醉科,537000

出　　处：《中国医药》2015年第2期223-227,共5页China Medicine

摘　　要：目的探讨地佐辛对苏芬太尼诱发的全身麻醉诱导期呛咳反应的预防作用。方法选取玉林市第一人民医院行全身麻醉插管手术患者124例，根据随机数据表将患者随机分为地佐辛组（63例）和对照组（61例），地佐辛组全身麻醉前5-10 min静脉注射给予0.1 mg/kg的地佐辛，而对照组给予等量0.9%氯化钠注射液。记录2组呛咳反应的发生率、呛咳前后的血压、心率的变化，同时对2组患者在给药前（T0）、给药后5 min（T1）、插管前（T2）、插管后（T3）、插管后2 min（T4）5个时间段的血压和心率进行比较。结果地佐辛组呛咳发生率[9.5%（6/63）]明显低于对照组[63.9%（39/61）]，差异有统计学意义（χ^2=30.86，P〈0.01）；地佐辛组和对照组发生呛咳患者呛咳后收缩压、舒张压和心率均有明显高于呛咳前[地佐辛组：收缩压为（134±10）mmHg比（114±10）mmHg，舒张压为（81±8）mmHg比（68±9）mmHg，心率为（86±10）次/min比（71±9）次/min，均P〈0.05；对照组：收缩压为（132±11）mmHg比（113±10）mmHg，舒张压为（81±8）mmHg比（68±9）mmHg，心率为（86±10）次/min比（72±9）次/min，均P〈0.05]，2组患者在T0、T1、T2、T3和T4时点心率、收缩压和舒张压比较差异无统计学意义（P〉0.05）。地佐辛组患者发生呼吸抑制、心动过缓和血压异常的例数分别为5、4和3例，而对照组分别为4、4和2例，地佐辛组和对照组患者的不良反应发生率差异无统计学意义[19.0%（12/63）比16.4%（10/61）]（χ^2=0.13，P=0.94）。结论全身麻醉前5-10 min静脉给予0.1 mg/kg的地佐辛能够明显抑制苏芬太尼引起的呛咳反应。ObjectiveTo investigate the impact of dezocine on the prevention of sufentanilinduced cough during anesthesia induction.MethodsTotally 124 surgical patients who received general anesthesia were randomly divided into two groups, with 63 cases in dezocine group and 61 cases in control group. The patients were given intravenous dezocine 0.1 mg/kg in indezocine group and equal volume of 0.9% saline injection in control group 510 min before the induction of general anesthesia. The occurrence and degree of cough were recorded within 1 minute after sufentanyl injection, including hemodynamic changes before and after cough. Heart rate（HR）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were recorded before administration （T0）,5 minutes after administration （T1）, before intubation （T2）, after intubation （T3）, 2 minutes after intubation （T4）.Results Totally 6 patients in the dezocine group had cough and 39 patients in the control group had cough; this difference was statistically different between the two groups[9.5%（6/63） vs 63.9%（39/61）] （χ^2=30.86,P〈0.01）. This difference of HR, SBP and DBP was statistically different before and after cough[dezocine group：SBP（134±10）mmHg vs （114±10）mmHg,DBP（81±8）mmHg vs （68±9）mmHg, HR（86±10）times/min vs （71±9）times/min, all P〈0.05; control group： SBP （132±11）mmHg vs （113±10）mmHg, DBP （81±8）mmHg vs （68±9）mmHg, HR（86±10）times/min vs （72±9）times/min,all P〈0.05]. HR, SBP and DBP in T0, T1, T2, T3 and T4 were not different between two groups （P〉0.05）. There was no difference of adverse reactions between two groups [19.0%（12/63） vs 16.4%（10/61）]（χ^2=0.13,P=0.94）.ConclusionIntravenous injection of dezocine prior to induction is effective in suppressing sufentanyl induced cough.

关 键 词：地佐辛 苏芬太尼 全身麻醉诱导 呛咳 

分 类 号：R614.2[医药卫生—麻醉学]