功能MRI揭示抑郁症脑结构及功能变化的应用及展望  

Application and prospect of functional magnetic resonance imaging reveals changes in brain structure and function in depression

作　　者：房俊芳[1,2] 王倩[1,2] 王滨[1,2] 李旭日[1] 毛宁[1,2] 

机构地区：[1]滨州医学院,烟台264003 [2]滨州医学院烟台附属医院放射科,烟台264100

出　　处：《磁共振成像》2015年第1期52-57,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:30470518)

摘　　要：抑郁症是由多种因素导致的心境障碍性疾病,主要表现为情绪低落,悲观,严重者甚至会有自杀倾向。有研究发现抑郁症与脑部某些神经联系减低及神经递质减少有关。随着功能MRI的发展,越来越多的人将功能MRI用于抑郁症的研究,以期阐明其发病机制。与传统的成像方式相比,它能反应脑白质微结构的变化并将相应脑区的功能状态影像化,有利于更加直观地分析研究脑结构与功能之间的关系。Depression is a mood disorder that is caused by a variety of factors, its main manifestation is depression, pessimism, some even become suicidal. Studies have found that depression is due to the reduction of certain brain nerve connections and neurotransmitter. With the development of functional magnetic resonance imaging, more and more people apply functional magnetic resonance imaging to studying depression, in order to elucidate the mechanism. Compared with the traditional imaging method, it can respond to changes in brain white matter microstructure and function image corresponding brain regions, which is conducive to a more intuitive analysis of the relationship between structure and function of brain.

关 键 词：抑郁症 脑疾病 磁共振成像 扩散张量成像 磁共振波谱学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749[医药卫生—诊断学]