蓬莱市健康人群新布尼亚病毒感染的血清学调查  

Serological investigation of the new virus Bunia infection among healthy population in Penglai City

作　　者：周淑琴[1] 宁福江[1] 孟淑欣 纪经海[1] 刘姗姗[1] 丁淑军[2] 王显军[2] 

机构地区：[1]蓬莱市疾病预防控制中心,山东烟台265600 [2]山东省疾病预防控制中心,山东济南250014

出　　处：《现代预防医学》2015年第3期476-478,共3页Modern Preventive Medicine

基　　金：国家自然科学青年基金项目(81102171);山东省医药卫生科技发展计划(2011HZ055);山东省科学技术发展计划(2012GHZ30031)

摘　　要：目的了解蓬莱市健康人群发热伴血小板减少综合征布尼亚病毒（SFTSV）感染情况,并分析其分布规律及流行因素,为控制疫情提供理论依据。方法采用多阶段整群随机抽样方法抽取健康人群1 525人,采集其血液标本并分离血清,采用间接酶联免疫吸附实验（ELISA）检测人群中新布尼亚病毒特异性Ig G抗体,并采用统计学方法对不同年龄组人群、不同时间采集人群血清抗体阳性率进行比较。结果 1 525人份血清中,新布尼亚病毒特异性Ig G抗体阳性138份,阳性率为9.05%,男性人群抗体阳性率为9.28%（61/657）,女性抗体阳性率为8.87%（77/868）,两者差异无统计学意义（χ^2=0.078,P〉0.05）。各年龄组人群均有感染,以61～70岁年龄组人群新布尼亚病毒抗体阳性率最高,各年龄组人群抗体阳性率组间的差异具有统计学意义（χ^2=46.86,P〈0.05）,农民抗体阳性率明显高于学生（χ^2=6.45,P〈0.05）,流行后期人群抗体阳性率高于流行期人群抗体水平（χ^2=9.36,P〈0.01）。结论蓬莱市健康人群中发热伴血小板减少综合征布尼亚病毒抗体阳性率较高,提示大多数SFTSV病毒感染后宿主体内产生的抗体可能会持续较长时间,为我们了解疾病的发生、发展规律提供了基础的理论数据。该病毒在蓬莱市流行强度较强,应引起高度重视。Objective To explore the infection in the healthy population of Penglai City who have a severe fever with thrombocytopenia syndrome bunyavirus（SFTSV）, and to analyze the distribution and epidemic factors in order to provide theoretical evidences for preventing the epidemic. Methods A total of 1525 people were selected by multistage randomized cluster sampling.Their serum samples were collected and were detected for SFTSV-specific Ig G antibody by indirect enzyme-linked immune sorbent assay（ELISA）. The positive seroprevalence antibody rates in healthy people were compared by statistical methods between different ages and different times for specimens＇ collection and so on. Results 138 of 1525 serum samples were detected to be positive for SFTSV-specific Ig G antibody, with a positive rate of 9.05%. The positive rate of SFTSV-specific Ig G antibody was 9.28%（61/657）for males and 8.87%（77/868） for females. There was no significant difference between genders（χ^2=0.078, P〈0.05）. Every age group was infected with SFTSV and the antibody rates were significantly different among age groups（χ^2=46.86, P〈0.05）. The highest positive rate was in the age group of 61-70. The positive rate of peasants was significantly higher than that of students（χ^2=6.45,P〈0.05）. The positive rate of SFTSV-specific Ig G antibody during post-epidemic periods was significantly higher than that during the epidemic period. Conclusion In healthy people in Penglai City, the high positive rate of the antibody of SFTSV suggests that SFTSV-specific Ig G antibody may persist for a long time after infecting with SFTSV, which will provide the theoretic evidence for the principle of the development of the disease. Because it is severe in Penglai City, we should take more attention.

关 键 词：发热伴血小板减少综合征 新布尼亚病毒 酶联免疫吸附实验 血清学调查 

分 类 号：R193[医药卫生—卫生事业管理]