共固化法激光快速成形制备个体化生物陶瓷支架的探讨  

Fabrication of porous ceramic scaffolds by co-curation stereolithography technique

作　　者：杜大江[1] 邵林[1] 韩剑锋[1] 刘真[2] 牛田多加志[3] 古川克子[3] 

机构地区：[1]哈尔滨医科大学附属第二医院骨科,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属第二医院科研实验中心,黑龙江哈尔滨150081 [3]东京大学工学部再生医工学研究室

出　　处：《哈尔滨医科大学学报》2014年第6期464-467,共4页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(LC201020);黑龙江省卫生厅科研课题(2010-094);哈尔滨市科技创新人才专项基金(2011RFLYSO31);黑龙江省教育厅海外学人科研资助项目(1155h014)

摘　　要：目的研究利用共固化法激光快速成形制备个体化生物陶瓷支架的可行性。方法首先建立立方纵孔生物陶瓷支架三维数字模型,利用激光快速成形技术制备的光硬化树脂负型母板实体,分别用传统聚乙烯醇和光硬化树脂作为结合剂与三磷酸钙粉末混合制备粉浆并填充入负模板,后者烧结前紫外光照射共硬化3 h,随后高温烧结制备陶瓷支架,进行形态学观察和生物亲和性考察。结果传统聚乙烯醇组烧结的支架孔道结构融合且裂隙形成,而共固化法烧结的支架孔道结构精细无融合,无裂缝产生,生物亲和性良好。结论共固化法激光快速成形技术可以作为间接法制备个体化生物陶瓷支架的新技术应用于组织工程中。Objective To study the feasibility of fabricating porous ceramic scaffolds by co-curation stereolithography technique .Methods The 3 D digital model of the ceramic scaffold and the negative UV-cured resin mould were made by RP first , and then filled in with PVA or UV-curable resin for sintering .The co-curing group was undergoing pre-UV-treatment for 3 h before sintering .Results The morphological study showed that scaffolds from PVA group had fused pores and cracks , but the co-curing group scaffolds had well-controlled pore structure without fusion and cracks .Conclusion The co-curation stereolithography technique is feasible for tissue engineering scaffold fabrication .

关 键 词：快速成形 骨组织工程 个体化 陶瓷支架 

分 类 号：R318.01[医药卫生—生物医学工程]