成人生长激素缺乏症患者血浆致动脉粥样硬化指数与代谢组分变化的相关性分析  

Correlation between atherogenic index of plasma level and metabolism components in adult growth hormone deficiency patients

作　　者：夏佳佳[1] 郑晓雅[1] 李林蔓[1] 刘婵[1] 胡钰梅 陈婷颖 李晓枫[1] 任伟[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,重庆400016

出　　处：《解放军医学杂志》2014年第12期975-980,共6页Medical Journal of Chinese People's Liberation Army

基　　金：重庆市卫生局医学科学技术研究项目(2010-2-109);国家临床重点专科建设项目(2011)~~

摘　　要：目的探讨成人生长激素缺乏症(AGHD)患者血浆致动脉粥样硬化指数(AIP)水平变化及其与人体测量学指标、糖脂代谢指标和炎症介质高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)的相关性。方法回顾性分析重庆医科大学附属第一医院2009年6月-2012年9月确诊的40例AGHD患者(AGHD组)及同期在体检中心进行体检的40例健康人(对照组)的临床资料,比较两组的一般情况和血生化指标,计算AIP值、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、LDL-C/HDL-C比值、TC/HDL-C比值、TG/LDL-C比值并进行组间比较,采用pearson法分析AIP与各指标的相关性。结果与对照组相比,AGHD组BMI、腰围、腰臀比、FINS、HOMA-β、HOMA-IR、TC、TG、LDL/HDL-C、TC/HDL-C、hs-CPR、IL-6、AIP均明显增高,HDL-C明显降低,差异有统计学意义(P<0.05);两组年龄、身高、体脂率、臀围、血压、FPG、LDL-C、TG/LDL-C水平差异无统计学意义(P>0.05)。AIP值与腰围、腰臀比、FINS、HOMA-β、HOMA-IR、TC、LDL-C/HDL-C、TC/HDL-C、TG/LDL-C、hs-CPR、IL-6呈正相关(P<0.05),与年龄、性别、身高、BMI、体脂率、臀围、DBP、FPG、LDL-C无明显相关性(P>0.05)。多元线性回归分析显示,hs-CRP和IL-6是AIP的独立危险因素。结论 AGHD患者AIP水平显著高于健康人群,并与罹患心血管疾病的多种危险因素显著相关。Objective To investigate the correlation of atherogenic index of plasma （AIP） levels with anthropometrics, glycolipid metabolism markers and high-sensitivity C-reactive protein （hs-CRP）, interleukin-6 （IL-6） in adult growth hormone deficiency （AGHD） patients. Methods Retrospective analysis were carried out in 40 AGHD patients （AGHD group, admitted to First Affiliated Hospital of Chongqing Medical University） and 40 healthy adults from physical examination centre （control group） during June 2009 to September 2012. The general anthropometries and blood biochemical indexes were collected and compared between two groups. AIP, homeostasis model assessment-insulin resistance （HOMA-IR）, homeostasis model assessment β-cell function （HOMA-β）, LDL-C/HDL-C, TC/HDL-C, and TG/LDL-C were calculated and compared between two groups. The correlation between AIP and these indexes was analyzed using Pearson correlation. Results Compared with control group, body mass index （BMI）, waist circumference （WC）, waist-hip ratio （WHR）, fasting insulin （FINS）, HOMA-β, HOMA-IR, total cholesterol （TC）, triglyceride （TG）, LDL-C/HDL-C, TC/HDL-C, hs-CPR, IL-6, AIP were significant higher, but HDL-C levels were lower in AGHD group （P〈0.05）. There were no significant differences in gender, age, height, body fat rate, hip circumference, blood pressure, fasting plasma glucose （FPG）, LDL-C and TG/LDL-C between two groups （P〉0.05）. There was a positive association between AIP and all the WC, WHR, FINS, HOMA-β, HOMA-IR, TC, LDL-C/HDL-C, TC/HDL-C, TG/LDL-C, hs-CRP and IL-6 （r=0.349, 0.314, 0.347, 0.335, 0.297, 0.256, 0.576, 0.749, 0.702, 0.477, 0.226, respectively, P〈0.05）. Multiple linear regression analysis revealed that hs-CRP and IL-6 were independent risk factors of AIP. Conclusion AIP is significantly higher in AGHD patients than healthy people, and it shows a strong correlation with many risk factors for cardiovascular diseases.

关 键 词：成人生长激素缺乏症 血浆致动脉粥样硬化指数 心血管疾病 

分 类 号：R584.2[医药卫生—内分泌]